Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Accepted manuscripts
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Subject collections
    • Interviews
    • Sign up for alerts
  • About us
    • About DMM
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Outstanding paper prize
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contact
    • Contact DMM
    • Advertising
    • Feedback
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

User menu

  • Log in

Search

  • Advanced search
Disease Models & Mechanisms
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

supporting biologistsinspiring biology

Disease Models & Mechanisms

Advanced search

RSS   Twitter   Facebook   YouTube

  • Home
  • Articles
    • Accepted manuscripts
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Subject collections
    • Interviews
    • Sign up for alerts
  • About us
    • About DMM
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Outstanding paper prize
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contact
    • Contact DMM
    • Advertising
    • Feedback

Yeast

  • RESOURCE ARTICLE
    Sentinel interaction mapping – a generic approach for the functional analysis of human disease gene variants using yeast
    Barry P. Young, Kathryn L. Post, Jesse T. Chao, Fabian Meili, Kurt Haas, Christopher Loewen
    Disease Models & Mechanisms 2020 13: dmm044560 doi: 10.1242/dmm.044560 Published 8 July 2020

    Summary: Sentinel interaction mapping is a technique that employs systematic genetic interaction mapping to identify yeast-human genetic interactions, which can be used to rapidly functionalize human disease genes and their variants.

  • RESEARCH ARTICLE
    A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects
    Thomas Delerue, Déborah Tribouillard-Tanvier, Marlène Daloyau, Farnoosh Khosrobakhsh, Laurent Jean Emorine, Gaëlle Friocourt, Pascale Belenguer, Marc Blondel, Laetitia Arnauné-Pelloquin
    Disease Models & Mechanisms 2019 12: dmm036558 doi: 10.1242/dmm.036558 Published 7 February 2019

    Editor's choice: Mitochondria are conserved among eukaryotes and mutations in the factors that control their dynamics are causal for various human disorders. Hence, yeast models can be used for pharmacological screenings.

  • RESEARCH ARTICLE
    Yeast-model-based study identified myosin- and calcium-dependent calmodulin signalling as a potential target for drug intervention in chorea-acanthocytosis
    Piotr Soczewka, Damian Kolakowski, Iwona Smaczynska-de Rooij, Weronika Rzepnikowska, Kathryn R. Ayscough, Joanna Kaminska, Teresa Zoladek
    Disease Models & Mechanisms 2019 12: dmm036830 doi: 10.1242/dmm.036830 Published 28 January 2019

    Summary: Using the vps13Δ strain, a yeast model of the neurodegenerative disorder chorea-acanthocytosis, we found that its defects can be overcome by reduction of calcineurin activity and/or type-I-myosin activation.

  • SPECIAL ARTICLE
    Sophisticated lessons from simple organisms: appreciating the value of curiosity-driven research
    Robert J. Duronio, Patrick H. O'Farrell, Greenfield Sluder, Tin Tin Su
    Disease Models & Mechanisms 2017 10: 1381-1389; doi: 10.1242/dmm.031203

    Summary: Curiosity-driven research using simple organisms has and will continue to lead to fundamental discoveries about biology that are directly applicable to improving the human condition.

  • RESOURCE ARTICLE
    Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE
    Lucía F. Zacchi, John C. Dittmar, Michael J. Mihalevic, Annette M. Shewan, Benjamin L. Schulz, Jeffrey L. Brodsky, Kara A. Bernstein
    Disease Models & Mechanisms 2017 10: 1129-1140; doi: 10.1242/dmm.029926

    Summary: A novel high-throughput, automated, genome-wide yeast screen was used to identify genetic modifiers of the steady-state levels of proteins of the dystonia-associated torsinAΔE variant. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.

  • REVIEW
    Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapies
    Jean-Paul Lasserre, Alain Dautant, Raeka S. Aiyar, Roza Kucharczyk, Annie Glatigny, Déborah Tribouillard-Tanvier, Joanna Rytka, Marc Blondel, Natalia Skoczen, Pascal Reynier, Laras Pitayu, Agnès Rötig, Agnès Delahodde, Lars M. Steinmetz, Geneviève Dujardin, Vincent Procaccio, Jean-Paul di Rago
    Disease Models & Mechanisms 2015 8: 509-526; doi: 10.1242/dmm.020438

    Summary: In this Review, we discuss the use of budding yeast to understand mitochondrial diseases and help in the search for their treatments.

  • RESEARCH ARTICLE
    The unfolded protein response has a protective role in yeast models of classic galactosemia
    Evandro A. De-Souza, Felipe S. A. Pimentel, Caio M. Machado, Larissa S. Martins, Wagner S. da-Silva, Mónica Montero-Lomelí, Claudio A. Masuda
    Disease Models & Mechanisms 2014 7: 55-61; doi: 10.1242/dmm.012641
  • AT A GLANCE
    Mechanisms of protein-folding diseases at a glance
    Julie S. Valastyan, Susan Lindquist
    Disease Models & Mechanisms 2014 7: 9-14; doi: 10.1242/dmm.013474

Other subject collections

Articles

  • Accepted manuscripts
  • Latest complete issue
  • Issue archive
  • Archive by article type
  • Subject collections
  • Interviews
  • Sign up for alerts

About us

  • About DMM
  • Editors and Board
  • Editor biographies
  • Travelling Fellowships
  • Grants and funding
  • Journal Meetings
  • Workshops
  • The Company of Biologists

For Authors

  • Submit a manuscript
  • Aims and scope
  • Presubmission enquiries
  • Article types
  • Manuscript preparation
  • Cover suggestions
  • Editorial process
  • Promoting your paper
  • Open Access
  • Biology Open transfer

Journal Info

  • Journal policies
  • Rights and permissions
  • Media policies
  • Reviewer guide
  • Sign up for alerts

Contact

  • Contact DMM
  • Advertising
  • Feedback

Twitter   YouTube   LinkedIn

© 2021   The Company of Biologists Ltd   Registered Charity 277992