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Disease Models & Mechanisms

Valproic acid

RESEARCH ARTICLE

Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in Dictyostelium discoideum
Elizabeth Kelly, Devdutt Sharma, Christopher J. Wilkinson, Robin S. B. Williams

Disease Models & Mechanisms 2018 11: dmm035600 doi: 10.1242/dmm.035600 Published 21 August 2018

Editor's choice: Here, using a tractable model system, Dictyostelium discoideum, we show that diacylglycerol kinase activity might contribute to the cellular mechanism of action of the epilepsy and bipolar disorder treatment, valproic acid.