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Tuberculosis

  • REVIEW
    Neonatal and infant immunity for tuberculosis vaccine development: importance of age-matched animal models
    Laylaa Ramos, Joan K. Lunney, Mercedes Gonzalez-Juarrero
    Disease Models & Mechanisms 2020 13: dmm045740 doi: 10.1242/dmm.045740 Published 15 September 2020

    Summary: Vaccine development for tuberculosis requires understanding of neonatal and infant immunity. Here, we compare the animal models of neonatal and infant immunity and highlight the potential of piglets as important models for vaccine development.

  • RESEARCH ARTICLE
    Identification of protective postexposure mycobacterial vaccine antigens using an immunosuppression-based reactivation model in the zebrafish
    Henna Myllymäki, Mirja Niskanen, Hanna Luukinen, Mataleena Parikka, Mika Rämet
    Disease Models & Mechanisms 2018 11: dmm033175 doi: 10.1242/dmm.033175 Published 13 March 2018

    Summary: We characterize the reactivation of a latent mycobacterial infection and identify DNA-based vaccine candidates against the reactivation of tuberculosis using the adult zebrafish Mycobacterium marinum infection model.

  • RESEARCH ARTICLE
    Priming of innate antimycobacterial immunity by heat-killed Listeria monocytogenes induces sterilizing response in the adult zebrafish tuberculosis model
    Hanna Luukinen, Milka Marjut Hammarén, Leena-Maija Vanha-aho, Aleksandra Svorjova, Laura Kantanen, Sampsa Järvinen, Bruno Vincent Luukinen, Eric Dufour, Mika Rämet, Vesa Pekka Hytönen, Mataleena Parikka
    Disease Models & Mechanisms 2018 11: dmm031658 doi: 10.1242/dmm.031658 Published 29 January 2018

    Summary: Heat-killed Listeria monocytogenes induces immune responses that lead to increased clearance of mycobacterial infection in the adult zebrafish tuberculosis model via innate immune mechanisms.

  • RESEARCH ARTICLE
    Microglia activation in a pediatric rabbit model of tuberculous meningitis
    Elizabeth W. Tucker, Supriya Pokkali, Zhi Zhang, Vincent P. DeMarco, Mariah Klunk, Elizabeth S. Smith, Alvaro A. Ordonez, Marie-France Penet, Zaver Bhujwalla, Sanjay K. Jain, Sujatha Kannan
    Disease Models & Mechanisms 2016 9: 1497-1506; doi: 10.1242/dmm.027326

    Summary: A clinically relevant novel rabbit model provides robust microglial activation and neurological deficits as seen in children with pediatric central nervous system tuberculosis.

  • RESEARCH ARTICLE
    Mouse model of pulmonary cavitary tuberculosis and expression of matrix metalloproteinase-9
    Alvaro A. Ordonez, Rokeya Tasneen, Supriya Pokkali, Ziyue Xu, Paul J. Converse, Mariah H. Klunk, Daniel J. Mollura, Eric L. Nuermberger, Sanjay K. Jain
    Disease Models & Mechanisms 2016 9: 779-788; doi: 10.1242/dmm.025643

    Summary: We demonstrate for the first time a murine model that consistently produces pulmonary cavitary TB and provides a tractable and economical new tool for better understanding of cavitation.

  • RESOURCE ARTICLE
    CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections
    Mark R. Cronan, Allison F. Rosenberg, Stefan H. Oehlers, Joseph W. Saelens, Dana M. Sisk, Kristen L. Jurcic Smith, Sunhee Lee, David M. Tobin
    Disease Models & Mechanisms 2015 8: 1643-1650; doi: 10.1242/dmm.021394

    Summary: The authors apply the CLARITY and PACT techniques to image infectious structures located deep within whole adult zebrafish and mouse organs, enabling visualization of mycobacterial granulomas and host response without sectioning.

  • RESEARCH ARTICLE
    Lung necrosis and neutrophils reflect common pathways of susceptibility to Mycobacterium tuberculosis in genetically diverse, immune-competent mice
    Muhammad K. K. Niazi, Nimit Dhulekar, Diane Schmidt, Samuel Major, Rachel Cooper, Claudia Abeijon, Daniel M. Gatti, Igor Kramnik, Bulent Yener, Metin Gurcan, Gillian Beamer
    Disease Models & Mechanisms 2015 8: 1141-1153; doi: 10.1242/dmm.020867

    Summary: Molecular biomarkers of tuberculosis are identified and used to classify disease status of Diversity Outbred mice that have been infected with Mycobacterium tuberculosis.

  • RESEARCH ARTICLE
    Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis
    Scott M. Irwin, Emily Driver, Edward Lyon, Christopher Schrupp, Gavin Ryan, Mercedes Gonzalez-Juarrero, Randall J. Basaraba, Eric L. Nuermberger, Anne J. Lenaerts
    Disease Models & Mechanisms 2015 8: 591-602; doi: 10.1242/dmm.019570

    Summary: C3HeB/FeJ mice develop three morphologically distinct lesion types, which differ with respect to bacterial load, cellular composition and degree of immunopathology following low-dose aerosol infection with Mycobacterium tuberculosis.

  • RESEARCH ARTICLE
    Heterogeneous disease progression and treatment response in a C3HeB/FeJ mouse model of tuberculosis
    Jean-Philippe Lanoix, Anne J. Lenaerts, Eric L. Nuermberger
    Disease Models & Mechanisms 2015 8: 603-610; doi: 10.1242/dmm.019513

    Summary: C3HeB/FeJ mice develop a wide range of lesion types that alter drug response in a way that might better inform tuberculosis drug development.

  • RESEARCH ARTICLE
    The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection
    Vincenzo Torraca, Chao Cui, Ralf Boland, Jan-Paul Bebelman, Astrid M. van der Sar, Martine J. Smit, Marco Siderius, Herman P. Spaink, Annemarie H. Meijer
    Disease Models & Mechanisms 2015 8: 253-269; doi: 10.1242/dmm.017756

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