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Transgenic

  • RESEARCH ARTICLE
    Mild maternal hyperglycemia in INSC93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring
    Simone Renner, Ana Sofia Martins, Elisabeth Streckel, Christina Braun-Reichhart, Mattias Backman, Cornelia Prehn, Nikolai Klymiuk, Andrea Bähr, Andreas Blutke, Christina Landbrecht-Schessl, Annegret Wünsch, Barbara Kessler, Mayuko Kurome, Arne Hinrichs, Sietse-Jan Koopmans, Stefan Krebs, Elisabeth Kemter, Birgit Rathkolb, Hiroshi Nagashima, Helmut Blum, Mathias Ritzmann, Rüdiger Wanke, Bernhard Aigner, Jerzy Adamski, Martin Hrabě de Angelis, Eckhard Wolf
    Disease Models & Mechanisms 2019 12: dmm039156 doi: 10.1242/dmm.039156 Published 12 August 2019

    Editor's choice: Mild maternal hyperglycemia causes impaired glucose tolerance and metabolic alterations in wild-type neonatal offspring of INSC93S transgenic pigs, a novel large animal model for mutant INS gene-induced diabetes of youth (MIDY).

  • REVIEW
    Transgenic and physiological mouse models give insights into different aspects of amyotrophic lateral sclerosis
    Francesca De Giorgio, Cheryl Maduro, Elizabeth M. C. Fisher, Abraham Acevedo-Arozena
    Disease Models & Mechanisms 2019 12: dmm037424 doi: 10.1242/dmm.037424 Published 2 January 2019

    Summary: This Review compares two key types of amyotrophic lateral sclerosis (ALS) mouse models: transgenic mice and those that express genes at physiological levels. We explore the advantages of each type for studying pathomechanisms, to understand what they can teach us about ALS.

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