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Stem cells

  • RESEARCH ARTICLE
    Cells expressing PAX8 are the main source of homeostatic regeneration of adult mouse endometrial epithelium and give rise to serous endometrial carcinoma
    Dah-Jiun Fu, Andrea J. De Micheli, Mallikarjun Bidarimath, Lora H. Ellenson, Benjamin D. Cosgrove, Andrea Flesken-Nikitin, Alexander Yu. Nikitin
    Disease Models & Mechanisms 2020 13: dmm047035 doi: 10.1242/dmm.047035 Published 30 October 2020

    Summary: The study describes a single-cell transcriptomic atlas of the mouse uterus and shows that PAX8+ cells are responsible for long-term maintenance of endometrial epithelium and might represent the cell of origin of serous endometrial carcinoma.

  • RESOURCE ARTICLE
    Human embryoid bodies as a 3D tissue model of the extracellular matrix and α-dystroglycanopathies
    Alec R. Nickolls, Michelle M. Lee, Kristen Zukosky, Barbara S. Mallon, Carsten G. Bönnemann
    Disease Models & Mechanisms 2020 13: dmm042986 doi: 10.1242/dmm.042986 Published 26 June 2020

    Summary: Human stem cell culture methods enable the generation of extracellular matrix-containing tissue to study patient-specific pathology and experimental treatment of the α-dystroglycanopathies.

  • AT A GLANCE
    Disease modelling in human organoids
    Madeline A. Lancaster, Meritxell Huch
    Disease Models & Mechanisms 2019 12: dmm039347 doi: 10.1242/dmm.039347 Published 29 July 2019

    Summary: Human organoids are important tools for modelling disease. This At a Glance article summarises the current organoid models of several human diseases, and discusses future prospects for these technologies.

  • REVIEW
    Plasticity of differentiated cells in wound repair and tumorigenesis, part II: skin and intestine
    Joseph Burclaff, Jason C. Mills
    Disease Models & Mechanisms 2018 11: dmm035071 doi: 10.1242/dmm.035071 Published 31 August 2018

    Summary: This final installment of a two-part Review discusses how cycles of dedifferentiation and redifferentiation can promote tumorigenesis in the skin and intestine, showing how plasticity in these continuously renewing tissues might contribute to tumorigenesis.

  • RESEARCH ARTICLE
    A carcinogenic trigger to study the function of tumor suppressor genes in Schmidtea mediterranea
    Andromeda Van Roten, Amal Zohir Abo-Zeid Barakat, Annelies Wouters, Thao Anh Tran, Stijn Mouton, Jean-Paul Noben, Luca Gentile, Karen Smeets
    Disease Models & Mechanisms 2018 11: dmm032573 doi: 10.1242/dmm.032573 Published 16 August 2018

    Summary: Combining exposure to the human carcinogen cadmium with in silico and proteomic top-down approaches, we disclosed the conserved function of two novel tumor suppressor genes in planarian.

  • REVIEW
    Plasticity of differentiated cells in wound repair and tumorigenesis, part I: stomach and pancreas
    Joseph Burclaff, Jason C. Mills
    Disease Models & Mechanisms 2018 11: dmm033373 doi: 10.1242/dmm.033373 Published 23 July 2018

    Summary: Epithelial cells in diverse tissues have an innate plasticity program (recently dubbed ‘paligenosis’) such that differentiated cells can become regenerative upon large-scale insults to an organ. Thus, the proliferating, regenerative cells in an organ may not always derive directly from stem cells, which invites us to refine theories about the cell of origin of cancer such as the multi-hit model of tumorigenesis.

  • RESEARCH ARTICLE
    Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder
    Ekaterina Savchenko, Yajuvinder Singh, Henna Konttinen, Katarina Lejavova, Laura Mediavilla Santos, Alexandra Grubman, Virve Kärkkäinen, Velta Keksa-Goldsteine, Nikolay Naumenko, Pasi Tavi, Anthony R. White, Tarja Malm, Jari Koistinaho, Katja M. Kanninen
    Disease Models & Mechanisms 2017 10: 1089-1100; doi: 10.1242/dmm.029165

    Editors’ choice: This study demonstrates neurogenic alterations in the most common neurodegenerative disease of children and reports a novel function of the CLN5 protein.

  • REVIEW
    Gastrointestinal stem cells in health and disease: from flies to humans
    Hongjie Li, Heinrich Jasper
    Disease Models & Mechanisms 2016 9: 487-499; doi: 10.1242/dmm.024232

    Drosophila Collection: This Review highlights recent findings on intestinal stem cell (ISC) diversity in the GI tract of Drosophila, focusing on the role of ISCs in healthy and diseased conditions, and drawing parallels to vertebrate GI stem cells.

  • RESEARCH ARTICLE
    Human umbilical cord matrix-derived stem cells exert trophic effects on β-cell survival in diabetic rats and isolated islets
    Yunting Zhou, Qi Hu, Fuyi Chen, Juan Zhang, Jincheng Guo, Hongwu Wang, Jiang Gu, Lian Ma, Guyu Ho
    Disease Models & Mechanisms 2015 8: 1625-1633; doi: 10.1242/dmm.021857

    Summary: The newly identified paracrine role of umbilical cord stem cells highlights their therapeutic utilities to treat not only the autoimmune-mediated type 1 diabetes but also type 2 diabetes.

  • SPECIAL ARTICLE
    Advances in using MRI probes and sensors for in vivo cell tracking as applied to regenerative medicine
    Amit K. Srivastava, Deepak K. Kadayakkara, Amnon Bar-Shir, Assaf A. Gilad, Michael T. McMahon, Jeff W. M. Bulte
    Disease Models & Mechanisms 2015 8: 323-336; doi: 10.1242/dmm.018499

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