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Retinal degeneration

  • RESEARCH ARTICLE
    Immunomodulation with minocycline rescues retinal degeneration in juvenile neuronal ceroid lipofuscinosis mice highly susceptible to light damage
    Katharina Dannhausen, Christoph Möhle, Thomas Langmann
    Disease Models & Mechanisms 2018 11: dmm033597 doi: 10.1242/dmm.033597 Published 5 September 2018

    Summary: Here, we established a light-damage paradigm to model retinal degeneration in the juvenile neuronal ceroid lipofuscinosis mouse and showed the beneficial effects of minocycline on retinal pathology.

  • RESEARCH ARTICLE
    Pgc-1α repression and high-fat diet induce age-related macular degeneration-like phenotypes in mice
    Meng Zhang, Yi Chu, Joseph Mowery, Brandon Konkel, Susana Galli, Alexander C. Theos, Nady Golestaneh
    Disease Models & Mechanisms 2018 11: dmm032698 doi: 10.1242/dmm.032698 Published 16 August 2018

    Summary: A new mouse model has been established that exhibits characteristics of human age-related macular degeneration; the model will facilitate further studies of AMD disease mechanisms.

  • RESEARCH ARTICLE
    Retina-specific loss of Ikbkap/Elp1 causes mitochondrial dysfunction that leads to selective retinal ganglion cell degeneration in a mouse model of familial dysautonomia
    Yumi Ueki, Veronika Shchepetkina, Frances Lefcort
    Disease Models & Mechanisms 2018 11: dmm033746 doi: 10.1242/dmm.033746 Published 30 July 2018

    Summary: The elongator subunit IKBKAP/ELP1 is not required for development, but is essential for maintaining mitochondrial function and retina morphology. Loss of this subunit causes progressive, selective degeneration of retinal ganglion cells.

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