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Rat

  • RESOURCE ARTICLE
    Disease Ontology: improving and unifying disease annotations across species
    Susan M. Bello, Mary Shimoyama, Elvira Mitraka, Stanley J. F. Laulederkind, Cynthia L. Smith, Janan T. Eppig, Lynn M. Schriml
    Disease Models & Mechanisms 2018 11: dmm032839 doi: 10.1242/dmm.032839 Published 12 March 2018

    Summary: Analyzing diverse disease data requires a comprehensive, robust disease ontology to integrate annotations and retrieve accurate, interpretable results. MGD, RGD and DO are working in collaboration to achieve this goal.

  • RESEARCH ARTICLE
    Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat
    Philip M. Coan, Oliver Hummel, Ana Garcia Diaz, Marjorie Barrier, Neza Alfazema, Penny J. Norsworthy, Michal Pravenec, Enrico Petretto, Norbert Hübner, Timothy J. Aitman
    Disease Models & Mechanisms 2017 10: 297-306; doi: 10.1242/dmm.026716

    Summary: Comparative genome analyses identify candidate genes for hypertension and insulin resistance on rat chromosomes 12 and 16, and marked enrichment of insulin resistance genes in the syntenic regions of the human genome.

  • REVIEW
    Renal disease pathophysiology and treatment: contributions from the rat
    Linda J. Mullins, Bryan R. Conway, Robert I. Menzies, Laura Denby, John J. Mullins
    Disease Models & Mechanisms 2016 9: 1419-1433; doi: 10.1242/dmm.027276

    Summary: This Review highlights the key role that the rat continues to play in improving our understanding of the etiologies of renal pathologies, and how these insights have opened up new therapeutic avenues.

  • EDITORIAL
    A RATional choice for translational research?
    Tim Aitman, Paraminder Dhillon, Aron M. Geurts
    Disease Models & Mechanisms 2016 9: 1069-1072; doi: 10.1242/dmm.027706

    Summary: This Editorial introduces a new Special Collection, ‘Spotlight on Rat: Translational Impact’, providing a summary of the articles published in this launch issue and a flavour of what's to come, as well as highlighting the impact rat models have made and continue to make on understanding human disease.

  • AT A GLANCE
    Rodent models in neuroscience research: is it a rat race?
    Bart Ellenbroek, Jiun Youn
    Disease Models & Mechanisms 2016 9: 1079-1087; doi: 10.1242/dmm.026120

    Summary: In this At a Glance poster review, Ellenbroek and Youn describe important differences between rats and mice that impact on their use as model organisms for brain disorders.

  • REVIEW
    From integrative genomics to systems genetics in the rat to link genotypes to phenotypes
    Aida Moreno-Moral, Enrico Petretto
    Disease Models & Mechanisms 2016 9: 1097-1110; doi: 10.1242/dmm.026104

    Summary: This Review describes the most recent advances in the field of systems genetics, focusing on the rat. We cover from the first integrative genomics strategies (such as mapping of expression QTLs or eQTLs) and conclude with the most sophisticated gene network-based analyses in multiple systems and disease states.

  • REVIEW
    Rat models of spinal cord injury: from pathology to potential therapies
    Jacob Kjell, Lars Olson
    Disease Models & Mechanisms 2016 9: 1125-1137; doi: 10.1242/dmm.025833

    Summary: In this Review, we discuss the advantages and disadvantages of the rat for studies of experimental spinal cord injury and summarize the knowledge gained from such studies.

  • RESEARCH ARTICLE
    Fischer-344 Tp53-knockout rats exhibit a high rate of bone and brain neoplasia with frequent metastasis
    Sarah A. Hansen, Marcia L. Hart, Susheel Busi, Taybor Parker, Angela Goerndt, Kevin Jones, James M. Amos-Landgraf, Elizabeth C. Bryda
    Disease Models & Mechanisms 2016 9: 1139-1146; doi: 10.1242/dmm.025767

    Editors' choice: Transferring a Tp53-knockout allele from an outbred rat stock to the F344 inbred rat genetic background alters the spectrum of tumors, providing a model of early-onset brain and bone sarcomas.

  • RESEARCH ARTICLE
    A rat model for hepatitis E virus
    Yannick Debing, Niraj Mishra, Erik Verbeken, Kaat Ramaekers, Kai Dallmeier, Johan Neyts
    Disease Models & Mechanisms 2016 9: 1203-1210; doi: 10.1242/dmm.024406

    Summary: Rat hepatitis E virus strain LA-B350 is used as a model for antiviral studies for hepatitis E virus using a cDNA clone, replicon and in vivo studies.

  • RESOURCE ARTICLE
    New Wistar Kyoto and spontaneously hypertensive rat transgenic models with ubiquitous expression of green fluorescent protein
    Ana Isabel Garcia Diaz, Ben Moyon, Philip M. Coan, Neza Alfazema, Lara Venda, Kevin Woollard, Tim Aitman
    Disease Models & Mechanisms 2016 9: 463-471; doi: 10.1242/dmm.024208

    Summary: We have created two transgenic models expressing ubiquitous GFP in WKY and SHR rat lines to support in vivo and ex vivo studies. We show their characterisation and discuss their potential use for translational research.

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