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Disease Models & Mechanisms

Personalized genomics

RESEARCH ARTICLE

Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers
Adam D. Pfefferle, Yash N. Agrawal, Daniel C. Koboldt, Krishna L. Kanchi, Jason I. Herschkowitz, Elaine R. Mardis, Jeffrey M. Rosen, Charles M. Perou

Disease Models & Mechanisms 2016 9: 749-757; doi: 10.1242/dmm.025239

Editors' choice: Personalized therapeutic targets for triple-negative breast cancers remain an important unmet clinical need. Genomic profiling of murine Trp53-null tumors identified a number of promising drug targets conserved in humans.