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Notochord

  • RESEARCH ARTICLE
    Transformed notochordal cells trigger chronic wounds destabilizing the vertebral column and bone homeostasis
    Paco López-Cuevas, Luke Deane, Yushi Yang, Chrissy L Hammond, Erika Kague
    Disease Models & Mechanisms 2021 : dmm.047001 doi: 10.1242/dmm.047001 Published 12 February 2021
  • RESEARCH ARTICLE
    Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish
    Gianluca D'Agati, Elena María Cabello, Karl Frontzek, Elisabeth J. Rushing, Robin Klemm, Mark D. Robinson, Richard M. White, Christian Mosimann, Alexa Burger
    Disease Models & Mechanisms 2019 12: dmm039545 doi: 10.1242/dmm.039545 Published 16 July 2019

    Summary: An injection-based chordoma model in zebrafish shows that the hypothesized chordoma oncogene brachyury is insufficient, whereas EGFR and VEGFR2 are sufficient, to trigger notochord hyperplasia in our model.

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