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Nitric oxide

  • RESEARCH ARTICLE
    Disturbed nitric oxide signalling gives rise to congenital bicuspid aortic valve and aortopathy
    Joshua C. Peterson, Lambertus J. Wisse, Valerie Wirokromo, Tessa van Herwaarden, Anke M. Smits, Adriana C. Gittenberger-de Groot, Marie-José T. H. Goumans, J. Conny VanMunsteren, Monique R. M. Jongbloed, Marco C. DeRuiter
    Disease Models & Mechanisms 2020 13: dmm044990 doi: 10.1242/dmm.044990 Published 28 September 2020

    Summary: Nitric oxide defects link bicuspid aortic valve formation and aortopathy through inhibition of elastic fibre formation in vascular smooth muscle cells within the ascending aorta of Nos3−/− mice.

  • RESEARCH ARTICLE
    Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish
    Karishma Chhabria, Avgoustinos Vouros, Caroline Gray, Ryan B. MacDonald, Zhen Jiang, Robert Neil Wilkinson, Karen Plant, Eleni Vasilaki, Clare Howarth, Timothy J. A. Chico
    Disease Models & Mechanisms 2019 12: dmm039867 doi: 10.1242/dmm.039867 Published 25 September 2019

    Summary: Diabetes is associated with vascular and neurological impairments. The authors show that an NO donor ameliorates the glucose-exposure-induced dysfunction in the tectal neurovascular unit and whole-organism behaviour.

  • RESEARCH ARTICLE
    Heterozygous disruption of activin receptor-like kinase 1 is associated with increased arterial pressure in mice
    María González-Núñez, Adela S. Riolobos, Orlando Castellano, Isabel Fuentes-Calvo, María de los Ángeles Sevilla, Bárbara Oujo, Miguel Pericacho, Ignacio Cruz-Gonzalez, Fernando Pérez-Barriocanal, Peter ten Dijke, Jose M. López-Novoa
    Disease Models & Mechanisms 2015 8: 1427-1439; doi: 10.1242/dmm.019695

    Summary: Mice haploinsufficient for Alk1, a receptor for the TGF-β family, show hypertension, based on overactivation of the sympathetic nervous system and a reduction in the number of cholinergic neurons in the CNS.

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