Mouse
- A regulated NMD mouse model supports NMD inhibition as a viable therapeutic option to treat genetic diseases
Summary: Nonsense-mediated mRNA decay can be inhibited after completion of mammalian prenatal development without adverse effects in non-neurological, somatic tissues, indicating that such inhibition might be a viable therapeutic strategy.
- A mouse SWATH-mass spectrometry reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts
Editor's choice: This paper presents the MouseRefSWATH mouse reference spectral library as a standardized community resource for SWATH-mass spectrometry studies and the XenoSWATH pipeline for species-specific deconvolution of human xenograft proteomic data.
- Gallbladder wall abnormality in biliary atresia of mouse Sox17+/− neonates and human infants
Summary: Metaplastic gland formation in gallbladder walls is seen in both human BA and the mouse Sox17-haploinsufficient BA model, indicating its contribution to the pathogenesis of human BA.
- Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis
Summary: This study reports that RIPK3 in macrophages and endothelial cells protects against atherosclerosis progression in mice, providing novel information about unexpected roles for RIPK3 in an inflammatory vascular disease.
- A gene-edited mouse model of limb-girdle muscular dystrophy 2C for testing exon skipping
Summary: The most common SGCG mutation that causes LGMD 2C has been modeled in mice using gene editing, providing a platform for preclinical evaluation of multi-exon antisense therapy.
- Experimental models and tools to tackle glioblastoma
Summary: This Review discusses preclinical modelling of glioblastoma multiforme to understand its biology and develop therapies, with a focus on mammalian model systems.
- Generating mouse models for biomedical research: technological advances
Summary: Newer molecular technologies to precisely and efficiently manipulate the mammalian genome are enabling the production of more scientifically valuable animal models.
- Mice doubly deficient in Six4 and Six5 show ventral body wall defects reproducing human omphalocele
Summary: The homeobox genes Six4 and Six5 are involved in the regulation of cell proliferation and mesothelium formation in the primary body wall, and Six4−/−;Six5−/− mice are a suitable animal model for human middle-type omphalocele.
- Independent effects of dietary fat and sucrose content on chondrocyte metabolism and osteoarthritis pathology in mice
Summary: The contribution of metabolic factors to obesity-associated knee osteoarthritis is uncertain. Here, we show how dietary fat and sucrose independently alter cartilage metabolic enzymes and osteoarthritis pathophysiology in mice.
- Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos
Summary: Disruption of Vangl2-dependent planar-polarised processes in the posterior neuropore (PNP) neuroepithelium and surface ectoderm preclude zippering point biomechanical accommodation associated with Closure 5 formation at the completion of PNP closure.