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Mouse

  • RESEARCH ARTICLE
    Inducible expression of human C9ORF72 36x G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice
    F. W. Riemslagh, E. C. van der Toorn, R. F. M. Verhagen, A. Maas, L. W. J. Bosman, R. K. Hukema, R. Willemsen
    Disease Models & Mechanisms 2021 : dmm.044842 doi: 10.1242/dmm.044842 Published 11 January 2021
  • RESEARCH ARTICLE
    A regulated NMD mouse model supports NMD inhibition as a viable therapeutic option to treat genetic diseases
    Josh Echols, Amna Siddiqui, Yanying Dai, Viktoria Havasi, Richard Sun, Aneta Kaczmarczyk, Kim M. Keeling
    Disease Models & Mechanisms 2020 13: dmm044891 doi: 10.1242/dmm.044891 Published 27 August 2020

    Summary: Nonsense-mediated mRNA decay can be inhibited after completion of mammalian prenatal development without adverse effects in non-neurological, somatic tissues, indicating that such inhibition might be a viable therapeutic strategy.

  • RESOURCE ARTICLE
    A mouse SWATH-mass spectrometry reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts
    Lukas Krasny, Philip Bland, Jessica Burns, Nadia Carvalho Lima, Peter T. Harrison, Laura Pacini, Mark L. Elms, Jian Ning, Victor Garcia Martinez, Yi-Ru Yu, Sophie E. Acton, Ping-Chih Ho, Fernando Calvo, Amanda Swain, Beatrice A. Howard, Rachael C. Natrajan, Paul H. Huang
    Disease Models & Mechanisms 2020 13: dmm044586 doi: 10.1242/dmm.044586 Published 14 July 2020

    Editor's choice: This paper presents the MouseRefSWATH mouse reference spectral library as a standardized community resource for SWATH-mass spectrometry studies and the XenoSWATH pipeline for species-specific deconvolution of human xenograft proteomic data.

  • RESEARCH ARTICLE
    Gallbladder wall abnormality in biliary atresia of mouse Sox17+/− neonates and human infants
    Mami Uemura, Mayumi Higashi, Montri Pattarapanawan, Shohei Takami, Naoki Ichikawa, Hiroki Higashiyama, Taizo Furukawa, Jun Fujishiro, Yuki Fukumura, Takashi Yao, Tatsuro Tajiri, Masami Kanai-Azuma, Yoshiakira Kanai
    Disease Models & Mechanisms 2020 13: dmm042119 doi: 10.1242/dmm.042119 Published 3 April 2020

    Summary: Metaplastic gland formation in gallbladder walls is seen in both human BA and the mouse Sox17-haploinsufficient BA model, indicating its contribution to the pathogenesis of human BA.

  • RESEARCH ARTICLE
    Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis
    Sarah Colijn, Vijay Muthukumar, Jun Xie, Siqi Gao, Courtney T. Griffin
    Disease Models & Mechanisms 2020 13: dmm041962 doi: 10.1242/dmm.041962 Published 24 January 2020

    Summary: This study reports that RIPK3 in macrophages and endothelial cells protects against atherosclerosis progression in mice, providing novel information about unexpected roles for RIPK3 in an inflammatory vascular disease.

  • RESEARCH ARTICLE
    A gene-edited mouse model of limb-girdle muscular dystrophy 2C for testing exon skipping
    Alexis R. Demonbreun, Eugene J. Wyatt, Katherine S. Fallon, Claire C. Oosterbaan, Patrick G. Page, Michele Hadhazy, Mattia Quattrocelli, David Y. Barefield, Elizabeth M. McNally
    Disease Models & Mechanisms 2020 13: dmm040832 doi: 10.1242/dmm.040832 Published 4 November 2019

    Summary: The most common SGCG mutation that causes LGMD 2C has been modeled in mice using gene editing, providing a platform for preclinical evaluation of multi-exon antisense therapy.

  • REVIEW
    Experimental models and tools to tackle glioblastoma
    Faye L. Robertson, Maria-Angeles Marqués-Torrejón, Gillian M. Morrison, Steven M. Pollard
    Disease Models & Mechanisms 2019 12: dmm040386 doi: 10.1242/dmm.040386 Published 6 September 2019

    Summary: This Review discusses preclinical modelling of glioblastoma multiforme to understand its biology and develop therapies, with a focus on mammalian model systems.

  • AT A GLANCE
    Generating mouse models for biomedical research: technological advances
    Channabasavaiah B. Gurumurthy, Kevin C. Kent Lloyd
    Disease Models & Mechanisms 2019 12: dmm029462 doi: 10.1242/dmm.029462 Published 8 January 2019

    Summary: Newer molecular technologies to precisely and efficiently manipulate the mammalian genome are enabling the production of more scientifically valuable animal models.

  • RESEARCH ARTICLE
    Mice doubly deficient in Six4 and Six5 show ventral body wall defects reproducing human omphalocele
    Masanori Takahashi, Masaru Tamura, Shigeru Sato, Kiyoshi Kawakami
    Disease Models & Mechanisms 2018 11: dmm034611 doi: 10.1242/dmm.034611 Published 25 October 2018

    Summary: The homeobox genes Six4 and Six5 are involved in the regulation of cell proliferation and mesothelium formation in the primary body wall, and Six4−/−;Six5−/− mice are a suitable animal model for human middle-type omphalocele.

  • RESEARCH ARTICLE
    Independent effects of dietary fat and sucrose content on chondrocyte metabolism and osteoarthritis pathology in mice
    Elise L. Donovan, Erika Barboza Prado Lopes, Albert Batushansky, Mike Kinter, Timothy M. Griffin
    Disease Models & Mechanisms 2018 11: dmm034827 doi: 10.1242/dmm.034827 Published 31 August 2018

    Summary: The contribution of metabolic factors to obesity-associated knee osteoarthritis is uncertain. Here, we show how dietary fat and sucrose independently alter cartilage metabolic enzymes and osteoarthritis pathophysiology in mice.

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