Mouse
- Experimental models and tools to tackle glioblastoma
Summary: This Review discusses preclinical modelling of glioblastoma multiforme to understand its biology and develop therapies, with a focus on mammalian model systems.
- Generating mouse models for biomedical research: technological advances
Summary: Newer molecular technologies to precisely and efficiently manipulate the mammalian genome are enabling the production of more scientifically valuable animal models.
- Mice doubly deficient in Six4 and Six5 show ventral body wall defects reproducing human omphalocele
Summary: The homeobox genes Six4 and Six5 are involved in the regulation of cell proliferation and mesothelium formation in the primary body wall, and Six4−/−;Six5−/− mice are a suitable animal model for human middle-type omphalocele.
- Independent effects of dietary fat and sucrose content on chondrocyte metabolism and osteoarthritis pathology in mice
Summary: The contribution of metabolic factors to obesity-associated knee osteoarthritis is uncertain. Here, we show how dietary fat and sucrose independently alter cartilage metabolic enzymes and osteoarthritis pathophysiology in mice.
- Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos
Summary: Disruption of Vangl2-dependent planar-polarised processes in the posterior neuropore (PNP) neuroepithelium and surface ectoderm preclude zippering point biomechanical accommodation associated with Closure 5 formation at the completion of PNP closure.
- Disease Ontology: improving and unifying disease annotations across species
Summary: Analyzing diverse disease data requires a comprehensive, robust disease ontology to integrate annotations and retrieve accurate, interpretable results. MGD, RGD and DO are working in collaboration to achieve this goal.
- Lyplal1 is dispensable for normal fat deposition in mice
Summary: We demonstrate that the Lyplal1 gene is dispensable in mice, with important implications for interpretation of GWAS results linking Lyplal1 to metabolism and fat distribution. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.
- Trimebutine, a small molecule mimetic agonist of adhesion molecule L1, contributes to functional recovery after spinal cord injury in mice
Summary: Small molecule L1CAM mimetics, showing L1 functions by promoting neurite outgrowth and neuronal survival in vitro, are now shown in vivo, with correlated signal transduction, to promote recovery after injury.
- Genetic dissection of anterior segment dysgenesis caused by a Col4a1 mutation in mouse
Summary: Key pathogenic events in anterior segment dysgenesis, a congenital ocular disease with complex etiology, are recapitulated in a mouse model of Col4a1-related ASD.
- Show and tell: disclosure and data sharing in experimental pathology
Summary: Reproducibility of findings in experiments using model organisms has recently become a source of concern, particularly for translational science. We discuss factors affecting the interpretation and reliability of experimental pathology findings in the mouse, and how disclosure and transparent reporting are crucial for replicability.