Mitochondrial disease
- Feeding difficulties, a key feature of the Drosophila NDUFS4 mitochondrial disease model
Summary: The characterization of a novel Drosophila model of NDUFS4 mitochondrial disease revealed a pronounced defect in feeding abilities and recapitulated additional human disease features.
- Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology
Summary: Previous limitations are overcome in this first genetically tractable mouse model expressing invertebrate alternative oxidase, AOX, which can suppress pathological stresses in the mitochondrial respiratory chain.
- Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapies
Summary: In this Review, we discuss the use of budding yeast to understand mitochondrial diseases and help in the search for their treatments.