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Mitochondrial biogenesis

  • RESEARCH ARTICLE
    Early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in the KIKO mouse model of Friedreich ataxia
    Hong Lin, Jordi Magrane, Amy Rattelle, Anna Stepanova, Alexander Galkin, Elisia M. Clark, Yi Na Dong, Sarah M. Halawani, David R. Lynch
    Disease Models & Mechanisms 2017 10: 1343-1352; doi: 10.1242/dmm.030502

    Summary: Our findings identify early cerebellar mitochondrial biogenesis deficits as a potential mediator of cerebellar dysfunction and ataxia, and indicate a potential therapeutic target for early intervention of Friedreich ataxia.

  • RESEARCH ARTICLE
    Phenotypic rescue of a Drosophila model of mitochondrial ANT1 disease
    Suvi Vartiainen, Shanjun Chen, Jack George, Tea Tuomela, Kaisa R. Luoto, Kevin M. C. O’Dell, Howard T. Jacobs
    Disease Models & Mechanisms 2014 7: 635-648; doi: 10.1242/dmm.016527

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