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MicroRNA

  • RESEARCH ARTICLE
    Duchenne muscular dystrophy (DMD) cardiomyocyte-secreted exosomes promote the pathogenesis of DMD-associated cardiomyopathy
    Melanie Gartz, Chien-Wei Lin, Mark A. Sussman, Michael W. Lawlor, Jennifer L. Strande
    Disease Models & Mechanisms 2020 13: dmm045559 doi: 10.1242/dmm.045559 Published 13 November 2020

    Summary: This study examines the consequential effects of exposure to diseased exosomes in a cell model of Duchenne muscular dystrophy (DMD). The findings support a detrimental role for long-term DMD cardiac exosome exposure.

  • RESEARCH ARTICLE
    Circulating exosomal microRNAs as potential biomarkers of hepatic injury and inflammation in a murine model of glycogen storage disease type 1a
    Roberta Resaz, Davide Cangelosi, Martina Morini, Daniela Segalerba, Luca Mastracci, Federica Grillo, Maria Carla Bosco, Cristina Bottino, Irma Colombo, Alessandra Eva
    Disease Models & Mechanisms 2020 13: dmm043364 doi: 10.1242/dmm.043364 Published 18 September 2020

    Summary: Mice with glycogen storage disease type 1a (GSD1a) show altered expression of several microRNAs, correlated with various pathologic liver states. This might help us to understand the progression of the disease and the development of late GSD1a-associated complications.

  • RESEARCH ARTICLE
    Overexpression of microRNA-722 fine-tunes neutrophilic inflammation by inhibiting Rac2 in zebrafish
    Alan Y. Hsu, Decheng Wang, Theodore Gurol, Wenqing Zhou, Xiaoguang Zhu, Hsiu-Yi Lu, Qing Deng
    Disease Models & Mechanisms 2017 10: 1323-1332; doi: 10.1242/dmm.030791

    Summary: Identification of a microRNA that suppresses Rac2 expression and regulates neutrophil migration and systemic inflammation. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.

  • REVIEW
    MicroRNAs in the etiology of colorectal cancer: pathways and clinical implications
    Ashlee M. Strubberg, Blair B. Madison
    Disease Models & Mechanisms 2017 10: 197-214; doi: 10.1242/dmm.027441

    Summary: This Review provides an overview of some important microRNAs and their roles in colorectal cancer.

  • RESEARCH ARTICLE
    MicroRNA screening identifies a link between NOVA1 expression and a low level of IKAP in familial dysautonomia
    Mylène Hervé, El Chérif Ibrahim
    Disease Models & Mechanisms 2016 9: 899-909; doi: 10.1242/dmm.025841

    Summary: A miRNA screening conducted in olfactory stem cells from patients links the neuron-specific splicing factor NOVA1 to neurodegeneration in familial dysautonomia.

  • RESEARCH ARTICLE
    MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma
    Mohit Sachdeva, Melody J. Whitley, Jeffrey K. Mito, Yan Ma, Dina C. Lev, Diana M. Cardona, David G. Kirsch
    Disease Models & Mechanisms 2015 8: 867-875; doi: 10.1242/dmm.017897

    Summary: This work underscores the importance of studying cancer metastasis using in vivo model systems in addition to in vitro and transplant model systems.

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