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Microfluidics

  • REVIEW
    Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches
    Jelle J. F. Sleeboom, Hossein Eslami Amirabadi, Poornima Nair, Cecilia M. Sahlgren, Jaap M. J. den Toonder
    Disease Models & Mechanisms 2018 11: dmm033100 doi: 10.1242/dmm.033100 Published 16 March 2018

    Summary: This Review evaluates the recent contributions of cancer-on-a-chip models to our understanding of the tumor microenvironment and its role in the onset of metastasis. The authors also provide an outlook for future applications of this emerging technology.

  • RESOURCE ARTICLE
    Parallel imaging of Drosophila embryos for quantitative analysis of genetic perturbations of the Ras pathway
    Yogesh Goyal, Thomas J. Levario, Henry H. Mattingly, Susan Holmes, Stanislav Y. Shvartsman, Hang Lu
    Disease Models & Mechanisms 2017 10: 923-929; doi: 10.1242/dmm.030163

    Summary: Microfluidics, live imaging and systems biology techniques are combined to develop a new approach for the functional analysis of sequence variants in the highly conserved Ras signaling pathway.

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