Microenvironment
- A novel patient-derived orthotopic xenograft model of esophageal adenocarcinoma provides a platform for translational discoveries
Editor's choice: The patient-derived orthotopic xenograft model of gastroesophageal adenocarcinoma maintains the morphological and molecular characteristics despite being highly heterogeneous, emphasizing its use as a powerful investigational platform to evaluate new therapies.
- Modelling the MYC-driven normal-to-tumour switch in breast cancer
Summary: We present a MYC-driven transformation model of breast cancer that recapitulates the disease in vivo and which can be used to identify MYC-dependent cancer vulnerabilities.
- Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies
Summary: Here, we discuss the model systems for cancer metabolism studies and highlight their key strengths and pitfalls in addressing different questions, such as how the microenvironment affects cancer metabolism and response to therapy.