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Microenvironment

  • RESOURCE ARTICLE
    A novel patient-derived orthotopic xenograft model of esophageal adenocarcinoma provides a platform for translational discoveries
    Omkara Lakshmi Veeranki, Zhimin Tong, Alicia Mejia, Anuj Verma, Riham Katkhuda, Roland Bassett, Tae-Beom Kim, Jing Wang, Wenhua Lang, Barbara Mino, Luisa Solis, Charles Kingsley, William Norton, Ramesh Tailor, Ji Yuan Wu, Sunil Krishnan, Steven H. Lin, Mariela Blum, Wayne Hofstetter, Jaffer Ajani, Scott Kopetz, Dipen Maru
    Disease Models & Mechanisms 2019 : dmm.041004 doi: 10.1242/dmm.041004 Published 15 November 2019
  • RESEARCH ARTICLE
    Modelling the MYC-driven normal-to-tumour switch in breast cancer
    Corey Lourenco, Manpreet Kalkat, Kathleen E. Houlahan, Jason De Melo, Joseph Longo, Susan J. Done, Paul C. Boutros, Linda Z. Penn
    Disease Models & Mechanisms 2019 12: dmm038083 doi: 10.1242/dmm.038083 Published 26 July 2019

    Summary: We present a MYC-driven transformation model of breast cancer that recapitulates the disease in vivo and which can be used to identify MYC-dependent cancer vulnerabilities.

  • REVIEW
    Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies
    Alexander Muir, Laura V. Danai, Matthew G. Vander Heiden
    Disease Models & Mechanisms 2018 11: dmm035758 doi: 10.1242/dmm.035758 Published 7 August 2018

    Summary: Here, we discuss the model systems for cancer metabolism studies and highlight their key strengths and pitfalls in addressing different questions, such as how the microenvironment affects cancer metabolism and response to therapy.

  • REVIEW
    Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era
    Chansey J. Veinotte, Graham Dellaire, Jason N. Berman
    Disease Models & Mechanisms 2014 7: 745-754; doi: 10.1242/dmm.015784

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