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Disease Models & Mechanisms

Metastatic sublines

RESEARCH ARTICLE

Generation and characterisation of two D2A1 mammary cancer sublines to model spontaneous and experimental metastasis in a syngeneic BALB/c host
Ute Jungwirth, Antoinette van Weverwijk, Miriam J. Melake, Ann F. Chambers, Qiong Gao, Marc Fivaz, Clare M. Isacke

Disease Models & Mechanisms 2018 11: dmm031740 doi: 10.1242/dmm.031740 Published 18 January 2018

Summary: We describe two D2A1 mouse mammary cancer sublines with enhanced spontaneous metastasis in a syngeneic host, and highlight the limitations of in vitro assays to predict in vivo metastatic behaviour.