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Metabolism

  • RESOURCE ARTICLE
    Metabolomics and lipidomics in C. elegans using a single sample preparation
    Marte Molenaars, Bauke V. Schomakers, Hyung L. Elfrink, Arwen W. Gao, Martin A. T. Vervaart, Mia L. Pras-Raves, Angela C. Luyf, Reuben L. Smith, Mark G. Sterken, Jan E. Kammenga, Antoine H. C. van Kampen, Georges E. Janssens, Frédéric M. Vaz, Michel van Weeghel, Riekelt H. Houtkooper
    Disease Models & Mechanisms 2021 : dmm.047746 doi: 10.1242/dmm.047746 Published 2 March 2021
  • RESEARCH ARTICLE
    Independent effects of dietary fat and sucrose content on chondrocyte metabolism and osteoarthritis pathology in mice
    Elise L. Donovan, Erika Barboza Prado Lopes, Albert Batushansky, Mike Kinter, Timothy M. Griffin
    Disease Models & Mechanisms 2018 11: dmm034827 doi: 10.1242/dmm.034827 Published 31 August 2018

    Summary: The contribution of metabolic factors to obesity-associated knee osteoarthritis is uncertain. Here, we show how dietary fat and sucrose independently alter cartilage metabolic enzymes and osteoarthritis pathophysiology in mice.

  • REVIEW
    Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies
    Alexander Muir, Laura V. Danai, Matthew G. Vander Heiden
    Disease Models & Mechanisms 2018 11: dmm035758 doi: 10.1242/dmm.035758 Published 7 August 2018

    Summary: Here, we discuss the model systems for cancer metabolism studies and highlight their key strengths and pitfalls in addressing different questions, such as how the microenvironment affects cancer metabolism and response to therapy.

  • AT A GLANCE
    Immunometabolism in cancer at a glance
    Katrin Singer, Wan-Chen Cheng, Marina Kreutz, Ping-Chih Ho, Peter J. Siska
    Disease Models & Mechanisms 2018 11: dmm034272 doi: 10.1242/dmm.034272 Published 2 August 2018

    Summary: This ‘At a Glance’ review and accompanying poster address how tumors can negatively affect immune cells through depletion of critical nutrients or through production of toxic metabolic products.

  • REVIEW
    The contributions of cancer cell metabolism to metastasis
    Gloria Pascual, Diana Domínguez, Salvador Aznar Benitah
    Disease Models & Mechanisms 2018 11: dmm032920 doi: 10.1242/dmm.032920 Published 3 May 2018

    Summary: In this Review the authors summarize recent findings on how specific metabolic cues modulate and influence the behaviour, genome and epigenome of metastatic cancer cells. They also discuss how the crosstalk between metabolism and the epigenome of metastatic cells can be harnessed to develop new anti-metastatic therapies.

  • RESEARCH ARTICLE
    Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets
    John J. Shin, Qurratulain Aftab, Pamela Austin, Jennifer A. McQueen, Tak Poon, Shu Chen Li, Barry P. Young, Calvin D. Roskelley, Christopher J. R. Loewen
    Disease Models & Mechanisms 2016 9: 1039-1049; doi: 10.1242/dmm.023374

    Summary: Altered metabolism in tumours creates metabolic acid stress in tumour cells, which is a target for chemotherapeutics. We identify six new complexes with roles in resistance to metabolic acid stress.

  • REVIEW
    The interplay between intestinal bacteria and host metabolism in health and disease: lessons from Drosophila melanogaster
    Adam C. N. Wong, Audrey S. Vanhove, Paula I. Watnick
    Disease Models & Mechanisms 2016 9: 271-281; doi: 10.1242/dmm.023408

    Drosophila Collection: Drosophila melanogaster is an ideal host in which to dissect the impact of intestinal microbes on host metabolism.

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