Metabolism
- Independent effects of dietary fat and sucrose content on chondrocyte metabolism and osteoarthritis pathology in mice
Summary: The contribution of metabolic factors to obesity-associated knee osteoarthritis is uncertain. Here, we show how dietary fat and sucrose independently alter cartilage metabolic enzymes and osteoarthritis pathophysiology in mice.
- Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies
Summary: Here, we discuss the model systems for cancer metabolism studies and highlight their key strengths and pitfalls in addressing different questions, such as how the microenvironment affects cancer metabolism and response to therapy.
- Immunometabolism in cancer at a glance
Summary: This ‘At a Glance’ review and accompanying poster address how tumors can negatively affect immune cells through depletion of critical nutrients or through production of toxic metabolic products.
- The contributions of cancer cell metabolism to metastasis
Summary: In this Review the authors summarize recent findings on how specific metabolic cues modulate and influence the behaviour, genome and epigenome of metastatic cancer cells. They also discuss how the crosstalk between metabolism and the epigenome of metastatic cells can be harnessed to develop new anti-metastatic therapies.
- Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets
Summary: Altered metabolism in tumours creates metabolic acid stress in tumour cells, which is a target for chemotherapeutics. We identify six new complexes with roles in resistance to metabolic acid stress.
- The interplay between intestinal bacteria and host metabolism in health and disease: lessons from Drosophila melanogaster
Drosophila Collection: Drosophila melanogaster is an ideal host in which to dissect the impact of intestinal microbes on host metabolism.