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Mecp2

  • RESEARCH ARTICLE
    Restoration of motor learning in a mouse model of Rett syndrome following long-term treatment with a novel small-molecule activator of TrkB
    Ian Adams, Tao Yang, Frank M. Longo, David M. Katz
    Disease Models & Mechanisms 2020 13: dmm044685 doi: 10.1242/dmm.044685 Published 27 November 2020

    Editor's choice: Long-term intermittent treatment with a newly developed partial agonist of the TrkB neurotrophin receptor reverses deficits in motor learning and respiration in a mouse model of Rett syndrome.

  • RESEARCH ARTICLE
    Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation
    M. van der Vaart, O. Svoboda, B. G. Weijts, R. Espín-Palazón, V. Sapp, T. Pietri, M. Bagnat, A. R. Muotri, D. Traver
    Disease Models & Mechanisms 2017 10: 1439-1451; doi: 10.1242/dmm.026922

    Summary: As shown by evaluating the levels of pro- and anti-inflammatory cytokines in mecp2-null zebrafish, Mecp2 is required for tnfa expression during zebrafish development and inflammation.

  • RESEARCH ARTICLE
    A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice
    Wei Li, Alba Bellot-Saez, Mary L. Phillips, Tao Yang, Frank M. Longo, Lucas Pozzo-Miller
    Disease Models & Mechanisms 2017 10: 837-845; doi: 10.1242/dmm.029959

    Editors' choice: The brain-penetrant BDNF loop domain mimetic LM22A-4 improves synaptic plasticity and spatial discrimination memory in Rett syndrome mice, making it a promising therapeutic candidate for the treatment of hippocampal dysfunction.

  • RESEARCH ARTICLE
    Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs
    José A. Herrera, Christopher S. Ward, Meagan R. Pitcher, Alan K. Percy, Steven Skinner, Walter E. Kaufmann, Daniel G. Glaze, Xander H. T. Wehrens, Jeffrey L. Neul
    Disease Models & Mechanisms 2015 8: 363-371; doi: 10.1242/dmm.020131
  • RESEARCH ARTICLE
    A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome
    Miriam Kron, Min Lang, Ian T. Adams, Michael Sceniak, Frank Longo, David M. Katz
    Disease Models & Mechanisms 2014 7: 1047-1055; doi: 10.1242/dmm.016030

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