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Liver

  • RESEARCH ARTICLE
    Circulating exosomal microRNAs as potential biomarkers of hepatic injury and inflammation in a murine model of glycogen storage disease type 1a
    Roberta Resaz, Davide Cangelosi, Martina Morini, Daniela Segalerba, Luca Mastracci, Federica Grillo, Maria Carla Bosco, Cristina Bottino, Irma Colombo, Alessandra Eva
    Disease Models & Mechanisms 2020 13: dmm043364 doi: 10.1242/dmm.043364 Published 18 September 2020

    Summary: Mice with glycogen storage disease type 1a (GSD1a) show altered expression of several microRNAs, correlated with various pathologic liver states. This might help us to understand the progression of the disease and the development of late GSD1a-associated complications.

  • RESEARCH ARTICLE
    DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of fibrolamellar carcinoma
    Sofia de Oliveira, Ruth A. Houseright, Benjamin G. Korte, Anna Huttenlocher
    Disease Models & Mechanisms 2020 13: dmm042564 doi: 10.1242/dmm.042564 Published 30 April 2020

    Summary: Inflammation and Caspase-a activation occur early in a new zebrafish model for fibrolamellar carcinoma (FLC). Pharmacological inhibition of TNFα secretion and caspase-1 might be useful approaches to treat FLC patients.

  • RESEARCH ARTICLE
    Characterization of high- and low-risk hepatocellular adenomas by magnetic resonance imaging in an animal model of glycogen storage disease type 1A
    Roberta Resaz, Francesca Rosa, Federica Grillo, Luca Basso, Daniela Segalerba, Andrea Puglisi, Maria Carla Bosco, Luca Mastracci, Carlo E. Neumaier, Luigi Varesio, Alessandra Eva
    Disease Models & Mechanisms 2019 12: dmm038026 doi: 10.1242/dmm.038026 Published 5 April 2019

    Summary: High-risk adenomas display magnetic resonance imaging (MRI) features clearly distinguishable from those exhibited by low-risk adenomas, suggesting the possibility of applying MRI to humans for non-invasive diagnostic purposes.

  • RESEARCH ARTICLE
    Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice
    Sabela Diaz-Castroverde, Almudena Gómez-Hernández, Silvia Fernández, Gema García-Gómez, Marianna Di Scala, Gloria González-Aseguinolaza, Elisa Fernández-Millán, Águeda González-Rodríguez, María García-Bravo, Pierre Chambon, Carmen Álvarez, Liliana Perdomo, Nuria Beneit, Oscar Escribano, Manuel Benito
    Disease Models & Mechanisms 2016 9: 1271-1281; doi: 10.1242/dmm.025288

    Summary: The specific hepatic expression of insulin receptor isoform A, but not isoform B, is able to revert, in the long term, the global glucose intolerance observed in diabetic mice.

  • AT A GLANCE
    Drosophila tools and assays for the study of human diseases
    Berrak Ugur, Kuchuan Chen, Hugo J. Bellen
    Disease Models & Mechanisms 2016 9: 235-244; doi: 10.1242/dmm.023762

    Editors' choice - Drosophila Collection: In this review and accompanying poster, we highlight the physiological and molecular parallels between fly and human organs that validate the use of Drosophila to study the molecular pathogenesis underlying human diseases.

  • RESEARCH ARTICLE
    The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders
    Hille Fieten, Yadvinder Gill, Alan J. Martin, Mafalda Concilli, Karen Dirksen, Frank G. van Steenbeek, Bart Spee, Ted S. G. A. M. van den Ingh, Ellen C. C. P. Martens, Paola Festa, Giancarlo Chesi, Bart van de Sluis, Roderick H. J. H. Houwen, Adrian L. Watson, Yurii S. Aulchenko, Victoria L. Hodgkinson, Sha Zhu, Michael J. Petris, Roman S. Polishchuk, Peter A. J. Leegwater, Jan Rothuizen
    Disease Models & Mechanisms 2016 9: 25-38; doi: 10.1242/dmm.020263

    Summary: Labrador retrievers with hereditary copper toxicosis are a useful new model for copper-metabolism disorders.

  • RESEARCH ARTICLE
    Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice
    Margarita Vida, Ana Luisa Gavito, Francisco Javier Pavón, Dolores Bautista, Antonia Serrano, Juan Suarez, Sergio Arrabal, Juan Decara, Miguel Romero-Cuevas, Fernando Rodríguez de Fonseca, Elena Baixeras
    Disease Models & Mechanisms 2015 8: 721-731; doi: 10.1242/dmm.019166

    Summary: The administration of rIL-6 might contribute to the aggravation of fatty liver disease through increasing lipogenesis in HFD-induced obesity.

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