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Leukemia

  • RESEARCH ARTICLE
    suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types
    Felix Oppel, Dong H. Ki, Mark W. Zimmerman, Kenneth N. Ross, Ting Tao, Hui Shi, Shuning He, Jon C. Aster, A. Thomas Look
    Disease Models & Mechanisms 2020 13: dmm042341 doi: 10.1242/dmm.042341 Published 27 August 2020

    Summary: In p53- and nf1-deficient zebrafish, onset of MPNSTs, as well as diverse other tumors, is accelerated by loss of the suz12 tumor suppressor, accompanied by global reduction in H3K27me3 marks and increased Ras-Mapk signaling.

  • AT A GLANCE
    Modeling hematopoietic disorders in zebrafish
    Martina Konantz, Christoph Schürch, Pauline Hanns, Joëlle S. Müller, Loïc Sauteur, Claudia Lengerke
    Disease Models & Mechanisms 2019 12: dmm040360 doi: 10.1242/dmm.040360 Published 6 September 2019

    Summary: This At A Glance article and poster summarize the last 20 years of research in zebrafish models for hematopoietic disorders, highlighting how these models were created and are being applied for translational research.

  • RESEARCH ARTICLE
    Leukemia development initiated by deletion of RBP-J: mouse strain, deletion efficiency and cell of origin
    Brian Chipman Belyea, Fang Xu, Maria Luisa Soledad Sequeira-Lopez, Roberto Ariel Gomez
    Disease Models & Mechanisms 2018 11: dmm036731 doi: 10.1242/dmm.036731 Published 18 December 2018

    Summary: Using a mouse model of precursor B-cell leukemia, we have investigated influencing factors on leukemia genesis, including genetic background, cell of origin and deletion efficiency.

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