Ischemia
- Intramyocardial angiogenetic stem cells and epicardial erythropoietin save the acute ischemic heart
Summary: Cardiac mesenchymal stem cells respond early to myocardial infarction. Their regenerative capacity is directly upregulated by optimized stimulation of the heart through epicardial erythropoietin delivery.
- CD40-mediated HIF-1α expression underlying microangiopathy in diabetic nerve pathology
Summary: This study provides a new therapeutic strategy for diabetic neuropathy, by demonstrating CD40 as a key mediator of microangiopathy leading to HIF-1α expression in endothelial cells.
- Pathophysiological and behavioral deficits in developing mice following rotational acceleration-deceleration traumatic brain injury
Summary: A neonatal mouse model that mimics abused head trauma in children offers a novel and reliable tool for finding mechanisms underlying the trauma and assessing treatments.