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Ischemia

  • RESEARCH ARTICLE
    Intramyocardial angiogenetic stem cells and epicardial erythropoietin save the acute ischemic heart
    Christian Klopsch, Anna Skorska, Marion Ludwig, Heiko Lemcke, Gabriela Maass, Ralf Gaebel, Martin Beyer, Cornelia Lux, Anita Toelk, Karina Müller, Christian Maschmeier, Sarah Rohde, Petra Mela, Brigitte Müller-Hilke, Stefan Jockenhoevel, Brigitte Vollmar, Robert Jaster, Robert David, Gustav Steinhoff
    Disease Models & Mechanisms 2018 11: dmm033282 doi: 10.1242/dmm.033282 Published 22 June 2018

    Summary: Cardiac mesenchymal stem cells respond early to myocardial infarction. Their regenerative capacity is directly upregulated by optimized stimulation of the heart through epicardial erythropoietin delivery.

  • RESEARCH ARTICLE
    CD40-mediated HIF-1α expression underlying microangiopathy in diabetic nerve pathology
    Hung-Wei Kan, Jung-Hsien Hsieh, Hsiung-Fei Chien, Yea-Huey Lin, Ti-Yen Yeh, Chi-Chao Chao, Sung-Tsang Hsieh
    Disease Models & Mechanisms 2018 11: dmm033647 doi: 10.1242/dmm.033647 Published 26 April 2018

    Summary: This study provides a new therapeutic strategy for diabetic neuropathy, by demonstrating CD40 as a key mediator of microangiopathy leading to HIF-1α expression in endothelial cells.

  • RESEARCH ARTICLE
    Pathophysiological and behavioral deficits in developing mice following rotational acceleration-deceleration traumatic brain injury
    Guoxiang Wang, Yi Ping Zhang, Zhongwen Gao, Lisa B. E. Shields, Fang Li, Tianci Chu, Huayi Lv, Thomas Moriarty, Xiao-Ming Xu, Xiaoyu Yang, Christopher B. Shields, Jun Cai
    Disease Models & Mechanisms 2018 11: dmm030387 doi: 10.1242/dmm.030387 Published 30 January 2018

    Summary: A neonatal mouse model that mimics abused head trauma in children offers a novel and reliable tool for finding mechanisms underlying the trauma and assessing treatments.

  • CLINICAL PUZZLE
    Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity
    Robert Nunan, Keith G. Harding, Paul Martin
    Disease Models & Mechanisms 2014 7: 1205-1213; doi: 10.1242/dmm.016782

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