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Inflammation

  • RESOURCE ARTICLE
    A simple method for in vivo labelling of infiltrating leukocytes in the mouse retina using indocyanine green dye
    Dawn A. Sim, Colin J. Chu, Senthil Selvam, Michael B. Powner, Sidath Liyanage, David A. Copland, Pearse A. Keane, Adnan Tufail, Catherine A. Egan, James W. B. Bainbridge, Richard W. Lee, Andrew D. Dick, Marcus Fruttiger
    Disease Models & Mechanisms 2015 8: 1479-1487; doi: 10.1242/dmm.019018

    Summary: We show here that peripheral leukocytes can be labelled with ICG in vivo and then directly imaged as they invade the retina after inflammatory stimuli.

  • RESEARCH ARTICLE
    A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations
    Michael Buchert, Franziska Rohde, Moritz Eissmann, Niall Tebbutt, Ben Williams, Chin Wee Tan, Alexander Owen, Yumiko Hirokawa, Alexandra Gnann, Gertraud Orend, Gayle Orner, Rod H. Dashwood, Joan K. Heath, Matthias Ernst, Klaus-Peter Janssen
    Disease Models & Mechanisms 2015 8: 1361-1373; doi: 10.1242/dmm.019844

    Summary: The gpA33ΔN-Bcat mice provide a model that better mimics some aspects of sporadic colon cancer induction in humans in terms of tumor multiplicity and latency and site-specific (i.e. colon) tumor occurrence that coincides with upregulation of markers for human colorectal cancer progression.

  • RESEARCH ARTICLE
    miR-146a targets Fos expression in human cardiac cells
    Xavier Palomer, Eva Capdevila-Busquets, Gaia Botteri, Mercy M. Davidson, Cristina Rodríguez, José Martínez-González, Francisco Vidal, Emma Barroso, Tung O. Chan, Arthur M. Feldman, Manuel Vázquez-Carrera
    Disease Models & Mechanisms 2015 8: 1081-1091; doi: 10.1242/dmm.020768

    Summary: These findings demonstrate that Fos is a direct target of miR-146a activity and that downregulation of the Fos–AP-1 pathway by miR-146a can inhibit MMP-9 activity.

  • RESEARCH ARTICLE
    HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals
    Daniel Bandarra, John Biddlestone, Sharon Mudie, H.-Arno J. Müller, Sonia Rocha
    Disease Models & Mechanisms 2015 8: 169-181; doi: 10.1242/dmm.017285
  • RESEARCH ARTICLE
    Triptolide treatment reduces Alzheimer’s disease (AD)-like pathology through inhibition of BACE1 in a transgenic mouse model of AD
    Qi Wang, Bing Xiao, Shuqin Cui, Hailong Song, Yanjing Qian, Lin Dong, Haiting An, Yanqiu Cui, Wenjing Zhang, Yi He, Jianliang Zhang, Jian Yang, Feilong Zhang, Guanzheng Hu, Xiaoli Gong, Zhen Yan, Yan Zheng, Xiaomin Wang
    Disease Models & Mechanisms 2014 7: 1385-1395; doi: 10.1242/dmm.018218
  • RESEARCH ARTICLE
    Repositioning drugs for inflammatory disease – fishing for new anti-inflammatory agents
    Christopher J. Hall, Sophie M. Wicker, An-Tzu Chien, Alisha Tromp, Lisa M. Lawrence, Xueying Sun, Geoffrey W. Krissansen, Kathryn E. Crosier, Philip S. Crosier
    Disease Models & Mechanisms 2014 7: 1069-1081; doi: 10.1242/dmm.016873
  • RESEARCH ARTICLE
    Transient infection of the zebrafish notochord with E. coli induces chronic inflammation
    Mai Nguyen-Chi, Quang Tien Phan, Catherine Gonzalez, Jean-François Dubremetz, Jean-Pierre Levraud, Georges Lutfalla
    Disease Models & Mechanisms 2014 7: 871-882; doi: 10.1242/dmm.014498
  • RESEARCH ARTICLE
    Balance between the two kinin receptors in the progression of experimental focal and segmental glomerulosclerosis in mice
    Rafael Luiz Pereira, Raphael José Ferreira Felizardo, Marcos Antônio Cenedeze, Meire Ioshie Hiyane, Ênio José Bassi, Mariane Tami Amano, Clarice Sylvia Taemi Origassa, Reinaldo Correia Silva, Cristhiane Fávero Aguiar, Sylvia Mendes Carneiro, João Bosco Pesquero, Ronaldo Carvalho Araújo, Alexandre de Castro Keller, Renato C. Monteiro, Ivan Cruz Moura, Alvaro Pacheco-Silva, Niels Olsen Saraiva Câmara
    Disease Models & Mechanisms 2014 7: 701-710; doi: 10.1242/dmm.014548
  • RESEARCH REPORT
    Zebrafish tissue injury causes upregulation of interleukin-1 and caspase-dependent amplification of the inflammatory response
    Nikolay V. Ogryzko, Emily E. Hoggett, Sara Solaymani-Kohal, Simon Tazzyman, Timothy J. A. Chico, Stephen A. Renshaw, Heather L. Wilson
    Disease Models & Mechanisms 2014 7: 259-264; doi: 10.1242/dmm.013029

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