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Inflammation

  • RESEARCH ARTICLE
    Alcoholic hepatitis and metabolic disturbance in female mice: a more tractable model than Nrf2−/− animals
    Lozan Sheriff, Reenam S. Khan, Raquel Saborano, Richard Wilkin, Nguyet-Thin Luu, Ulrich L. Gunther, Stefan G. Hubscher, Philip N. Newsome, Patricia F. Lalor
    Disease Models & Mechanisms 2020 13: dmm046383 doi: 10.1242/dmm.046383 Published 29 December 2020

    Summary: We describe a simple murine model of alcoholic hepatitis (AH) to induce injury that recreates many of the key features of AH in human, without the need of challenging surgical procedures to administer ethanol. This will be valuable for testing new therapeutic treatments.

  • RESEARCH ARTICLE
    3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II
    Urmas Roostalu, Jacob Lercke Skytte, Casper Gravesen Salinas, Thomas Klein, Niels Vrang, Jacob Jelsing, Jacob Hecksher-Sørensen
    Disease Models & Mechanisms 2020 13: dmm045351 doi: 10.1242/dmm.045351 Published 18 December 2020

    Summary: We report a 3D quantitative imaging platform (using light-sheet fluorescence microscopy) that can reveal changes in beta cell volume and proliferation, and leukocyte infiltration in pancreata in mouse models of diabetes.

  • RESEARCH ARTICLE
    Akkermansia muciniphila promotes type H vessel formation and bone fracture healing by reducing gut permeability and inflammation
    Jiang-Hua Liu, Tao Yue, Zhong-Wei Luo, Jia Cao, Zi-Qi Yan, Ling Jin, Teng-Fei Wan, Ci-Jun Shuai, Zheng-Guang Wang, Yong Zhou, Ran Xu, Hui Xie
    Disease Models & Mechanisms 2020 13: dmm043620 doi: 10.1242/dmm.043620 Published 1 December 2020

    Summary: Akkermansia muciniphila reduces intestinal permeability and alleviates inflammation, inducing more PDGF-BB+ preosteoclasts and type H vessel formation in callus, thus promoting bone fracture healing.

  • CLINICAL PUZZLE
    Fibrodysplasia ossificans progressiva: current concepts from bench to bedside
    Arun-Kumar Kaliya-Perumal, Tom J. Carney, Philip W. Ingham
    Disease Models & Mechanisms 2020 13: dmm046441 doi: 10.1242/dmm.046441 Published 21 September 2020

    Summary: Fibrodysplasia ossificans progressiva is a rare disease characterised by progressive heterotopic bone formation. Here, we present a comprehensive summary of the recent literature on this debilitating condition and discuss approaches to solving this clinical puzzle.

  • RESOURCE ARTICLE
    A novel Cre-enabled tetracycline-inducible transgenic system for tissue-specific cytokine expression in the zebrafish: CETI-PIC3
    Sara Ibrahim, Arianna Harris-Kawano, Isra Haider, Raghavendra G. Mirmira, Emily K. Sims, Ryan M. Anderson
    Disease Models & Mechanisms 2020 13: dmm042556 doi: 10.1242/dmm.042556 Published 26 June 2020

    Summary: Here, we report a novel transgenic zebrafish system that permits tissue-specific, inducible and tunable expression of pro-inflammatory cytokines for modeling inflammatory diseases.

  • RESEARCH ARTICLE
    Genetic activation of Nrf2 reduces cutaneous symptoms in a murine model of Netherton syndrome
    Sukalp Muzumdar, Michael Koch, Hayley Hiebert, Andreas Bapst, Alessia Gravina, Wilhelm Bloch, Hans-Dietmar Beer, Sabine Werner, Matthias Schäfer
    Disease Models & Mechanisms 2020 13: dmm042648 doi: 10.1242/dmm.042648 Published 1 June 2020

    Summary: Nrf2 activation ameliorates the epidermal barrier defect and cutaneous inflammation in a mouse model of Netherton syndrome, suggesting the utility of NRF2-activating compounds in patients with this genetic disease.

  • RESEARCH ARTICLE
    DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of fibrolamellar carcinoma
    Sofia de Oliveira, Ruth A. Houseright, Benjamin G. Korte, Anna Huttenlocher
    Disease Models & Mechanisms 2020 13: dmm042564 doi: 10.1242/dmm.042564 Published 30 April 2020

    Summary: Inflammation and Caspase-a activation occur early in a new zebrafish model for fibrolamellar carcinoma (FLC). Pharmacological inhibition of TNFα secretion and caspase-1 might be useful approaches to treat FLC patients.

  • RESEARCH ARTICLE
    Arx expansion mutation perturbs cortical development by augmenting apoptosis without activating innate immunity in a mouse model of X-linked infantile spasms syndrome
    Meagan S. Siehr, Cory A. Massey, Jeffrey L. Noebels
    Disease Models & Mechanisms 2020 13: dmm042515 doi: 10.1242/dmm.042515 Published 30 March 2020

    Editor's choice: We found non-cell-autonomous apoptosis and fewer Arx+ interneurons in neonatal neocortex of an X-linked infantile spasms syndrome Arx expansion model. Early estradiol therapy rescued Arx+ interneuron density, but did not prevent apoptosis.

  • REVIEW
    Biomarkers for Duchenne muscular dystrophy: myonecrosis, inflammation and oxidative stress
    Miranda D. Grounds, Jessica R. Terrill, Basma A. Al-Mshhdani, Marisa N. Duong, Hannah G. Radley-Crabb, Peter G. Arthur
    Disease Models & Mechanisms 2020 13: dmm043638 doi: 10.1242/dmm.043638 Published 2 March 2020

    Summary: This Review discusses biomarkers in blood and urine linked to myonecrosis, inflammation and oxidative stress, to enhance development of therapies for DMD, and the challenges to be overcome for clinical translation.

  • RESEARCH ARTICLE
    Notch4 activation aggravates NF-κB-mediated inflammation in HIV-1-associated nephropathy
    Rajni Vaid Puri, Sireesha Yerrathota, Trisha Home, Jessica Y. Idowu, V. Praveen Chakravarthi, Christopher J. Ward, Pravin C. Singhal, Gregory B. Vanden Heuvel, Timothy A. Fields, Madhulika Sharma
    Disease Models & Mechanisms 2019 12: dmm040642 doi: 10.1242/dmm.040642 Published 17 December 2019

    Summary: Notch4 activation contributes to the inflammation seen in HIV-associated nephropathy (HIVAN), and inhibition of Notch4 ameliorates inflammation and prolongs life in a mouse model of HIVAN.

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