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Humanized mouse

  • RESEARCH ARTICLE
    Pre-existing antibody-mediated adverse effects prevent the clinical development of a bacterial anti-inflammatory protein
    Angelino T. Tromp, Yuxi Zhao, Ilse Jongerius, Erik C. J. M. Heezius, Pauline Abrial, Maartje Ruyken, Jos A. G. van Strijp, Carla J. C. de Haas, András N. Spaan, Kok P. M. van Kessel, Thomas Henry, Pieter-Jan A. Haas
    Disease Models & Mechanisms 2020 13: dmm045534 doi: 10.1242/dmm.045534 Published 28 September 2020

    Summary: Chemotaxis inhibitory protein of Staphylococcus aureus dampens C5a-mediated responses in human-C5aR1 knock-in mice. Feasibility studies in a human phase I trial failed due to high levels of existing natural antibodies causing adverse effects.

  • RESEARCH ARTICLE
    Medroxyprogesterone acetate alters the vaginal microbiota and microenvironment in women and increases susceptibility to HIV-1 in humanized mice
    Jocelyn M. Wessels, Julie Lajoie, Maeve I. J. Hay Cooper, Kenneth Omollo, Allison M. Felker, Danielle Vitali, Haley A. Dupont, Philip V. Nguyen, Kristen Mueller, Fatemeh Vahedi, Joshua Kimani, Julius Oyugi, Juliana Cheruiyot, John N. Mungai, Alexandre Deshiere, Michel J. Tremblay, Tony Mazzulli, Jennifer C. Stearns, Ali A. Ashkar, Keith R. Fowke, Michael G. Surette, Charu Kaushic
    Disease Models & Mechanisms 2019 12: dmm039669 doi: 10.1242/dmm.039669 Published 23 October 2019

    Summary: MPA may increase susceptibility to HIV-1 in sex workers through the suppression of endogenous estrogen, reducing vaginal glycogen and α-amylase levels, which increases bacterial diversity, potentially reducing protective bacterial species such as lactobacilli.

  • RESOURCE ARTICLE
    Introduction of the human AVPR1A gene substantially alters brain receptor expression patterns and enhances aspects of social behavior in transgenic mice
    Rhonda Charles, Takeshi Sakurai, Nagahide Takahashi, Gregory A. Elder, Miguel A. Gama Sosa, Larry J. Young, Joseph D. Buxbaum
    Disease Models & Mechanisms 2014 7: 1013-1022; doi: 10.1242/dmm.017053

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