High-fat diet
- Independent effects of dietary fat and sucrose content on chondrocyte metabolism and osteoarthritis pathology in mice
Summary: The contribution of metabolic factors to obesity-associated knee osteoarthritis is uncertain. Here, we show how dietary fat and sucrose independently alter cartilage metabolic enzymes and osteoarthritis pathophysiology in mice.
- Pgc-1α repression and high-fat diet induce age-related macular degeneration-like phenotypes in mice
Summary: A new mouse model has been established that exhibits characteristics of human age-related macular degeneration; the model will facilitate further studies of AMD disease mechanisms.
- Dietary reversal of neuropathy in a murine model of prediabetes and metabolic syndrome
Summary: A mouse model of metabolic syndrome can be used to investigate peripheral nerve damage, enabling the development of mechanism-based therapies for neuropathy.