Hepatocellular carcinoma
- Reversion of tumor hepatocytes to normal hepatocytes during liver tumor regression in an oncogene-expressing transgenic zebrafish model
Summary: In an oncogene-addicted liver cancer zebrafish model, transformed cancer hepatocytes could be reverted to normal hepatocytes, as shown by Cre-loxP-mediated cell-lineage tracing.
- Molecular characterization of hepatocarcinogenesis using mouse models
Summary: We present initial data from systematic and longitudinal analyses of hepatocarcinogenesis using mouse models that reflect the human disease. This provides a rich resource for the analysis of biomarkers and sequential molecular alterations during disease progression.