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Disease Models & Mechanisms

Gastric carcinoids

RESEARCH ARTICLE

A knockin mouse model for human ATP4a^R703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies
Oriol Calvete, Andrea Varro, D. Mark Pritchard, Alicia Barroso, Marta Oteo, Miguel Ángel Morcillo, Pierfrancesco Vargiu, Steven Dodd, Miriam Garcia, José Reyes, Sagrario Ortega, Javier Benitez

Disease Models & Mechanisms 2016 9: 975-984; doi: 10.1242/dmm.025890

Summary: Gastric pathologies in an ATP4a knockin mouse model of a mutation responsible for the development of gastric neuroendocrine tumors in humans are prevented and reverted by adding HCl to drinking water.