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Fibrosis

  • RESEARCH ARTICLE
    Extracellular matrix induced by steroids and aging through a G-protein-coupled receptor in a Drosophila model of renal fibrosis
    Wenjing Zheng, Karen Ocorr, Marc Tatar
    Disease Models & Mechanisms 2020 13: dmm041301 doi: 10.1242/dmm.041301 Published 24 June 2020

    Summary: Drosophila kidney function in impaired by the steroid hormone ecdysone and by human aldosterone, and when ecdysone increases with age. Steroids induce fibrosis in the fly kidney by signaling through the Dopamine-Ecdysone receptor.

  • RESEARCH ARTICLE
    Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury
    Andrea Villar-Lorenzo, Patricia Rada, Esther Rey, Patricia Marañón, Ana I. Arroba, Beatriz Santamaría, Jorge Sáiz, Francisco J. Rupérez, Coral Barbas, Carmelo García-Monzón, Ángela M. Valverde, Águeda González-Rodríguez
    Disease Models & Mechanisms 2019 12: dmm038810 doi: 10.1242/dmm.038810 Published 16 July 2019

    Summary: IRS2 is a key mediator of IGF1R signalling in hepatic stellate cell activation in cholestatic liver injury.

  • RESEARCH ARTICLE
    Choroidal pericytes promote subretinal fibrosis after experimental photocoagulation
    Xueting Luo, Shiqi Yang, Jian Liang, Yuanqi Zhai, Mengxi Shen, Junran Sun, Yiji Feng, Xinmin Lu, Hong Zhu, Fenghua Wang, Xiaodong Sun
    Disease Models & Mechanisms 2018 11: dmm032060 doi: 10.1242/dmm.032060 Published 23 April 2018

    Summary: Using a laser-induced photocoagulation model with collagen 1α1-GFP reporter mice, we identified choroidal pericytes as potential therapeutic targets to prevent subretinal fibrosis for management of neovascular age-related macular degeneration.

  • RESOURCE ARTICLE
    Renal scar formation and kidney function following antibiotic-treated murine pyelonephritis
    Patrick D. Olson, Lisa K. McLellan, Alice Liu, Kelleigh E. Briden, Kristin M. Tiemann, Allyssa L. Daugherty, Keith A. Hruska, David A. Hunstad
    Disease Models & Mechanisms 2017 10: 1371-1379; doi: 10.1242/dmm.030130

    Summary: A new model of antibiotic-treated severe pyelonephritis offers a novel platform to study the molecular pathogenesis of pyelonephritis, response to antibiotic therapy, and sequelae, including fibrosis and renal scarring.

  • RESEARCH ARTICLE
    Upregulation of distinct collagen transcripts in post-surgery scar tissue: a study of conjunctival fibrosis
    Li-Fong Seet, Li Zhen Toh, Stephanie W. L. Chu, Sharon N. Finger, Jocelyn L. L. Chua, Tina T. Wong
    Disease Models & Mechanisms 2017 10: 751-760; doi: 10.1242/dmm.028555

    Summary: As well as providing an objective quantitative measure, distinct collagen genes may further aid in the characterization and definition of the development of fibrosis.

  • RESEARCH ARTICLE
    A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress
    Sian E. Piret, Eric Olinger, Anita A. C. Reed, M. Andrew Nesbit, Tertius A. Hough, Liz Bentley, Olivier Devuyst, Roger D. Cox, Rajesh V. Thakker
    Disease Models & Mechanisms 2017 10: 773-786; doi: 10.1242/dmm.029488

    Summary: A mouse model for renal fibrosis caused by uromodulin mutations reveals roles for ER stress and the unfolded protein response.

  • RESOURCE ARTICLE
    High- and ultrahigh-field magnetic resonance imaging of naïve, injured and scarred vocal fold mucosae in rats
    Ayami Ohno Kishimoto, Yo Kishimoto, David L. Young, Jinjin Zhang, Ian J. Rowland, Nathan V. Welham
    Disease Models & Mechanisms 2016 9: 1397-1403; doi: 10.1242/dmm.026526

    Summary: Magnetic resonance imaging is shown to allow the nondestructive assessment of acute injury and scar formation in vocal fold mucosa, as demonstrated ex vivo using a preclinical rat model.

  • RESEARCH ARTICLE
    Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targeting ex vivo
    Fariba Poosti, Bao Tung Pham, Dorenda Oosterhuis, Klaas Poelstra, Harry van Goor, Peter Olinga, Jan-Luuk Hillebrands
    Disease Models & Mechanisms 2015 8: 1227-1236; doi: 10.1242/dmm.020172

    Drug Discovery Collection: TGFβ induces renal fibrosis in ex vivo cultured precision-cut kidney slices, which can be attenuated by IFNγ.

  • RESEARCH ARTICLE
    Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis
    Elena Turola, Salvatore Petta, Ester Vanni, Fabiola Milosa, Luca Valenti, Rosina Critelli, Luca Miele, Livia Maccio, Vincenza Calvaruso, Anna L. Fracanzani, Marcello Bianchini, Nazarena Raos, Elisabetta Bugianesi, Serena Mercorella, Marisa Di Giovanni, Antonio Craxì, Silvia Fargion, Antonio Grieco, Calogero Cammà, Franco Cotelli, Erica Villa
    Disease Models & Mechanisms 2015 8: 1037-1046; doi: 10.1242/dmm.019950

    Summary: This study provides clinical and experimental evidence for the different roles played by excess calorie intake in the development of NAFLD and fibrosis; these diseases are dependent on age and reproductive status.

  • RESEARCH ARTICLE
    Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt/β-catenin-driven trans-differentiation of murine alveolar epithelial cells
    Kathrin Mutze, Sarah Vierkotten, Jadranka Milosevic, Oliver Eickelberg, Melanie Königshoff
    Disease Models & Mechanisms 2015 8: 877-890; doi: 10.1242/dmm.019117

    Summary: The authors identified proteins involved in Wnt/β-catenin-driven alveolar epithelial plasticity in lung injury and repair.

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