Fibrosis
- Extracellular matrix induced by steroids and aging through a G-protein-coupled receptor in a Drosophila model of renal fibrosis
Summary: Drosophila kidney function in impaired by the steroid hormone ecdysone and by human aldosterone, and when ecdysone increases with age. Steroids induce fibrosis in the fly kidney by signaling through the Dopamine-Ecdysone receptor.
- Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury
Summary: IRS2 is a key mediator of IGF1R signalling in hepatic stellate cell activation in cholestatic liver injury.
- Choroidal pericytes promote subretinal fibrosis after experimental photocoagulation
Summary: Using a laser-induced photocoagulation model with collagen 1α1-GFP reporter mice, we identified choroidal pericytes as potential therapeutic targets to prevent subretinal fibrosis for management of neovascular age-related macular degeneration.
- Renal scar formation and kidney function following antibiotic-treated murine pyelonephritis
Summary: A new model of antibiotic-treated severe pyelonephritis offers a novel platform to study the molecular pathogenesis of pyelonephritis, response to antibiotic therapy, and sequelae, including fibrosis and renal scarring.
- Upregulation of distinct collagen transcripts in post-surgery scar tissue: a study of conjunctival fibrosis
Summary: As well as providing an objective quantitative measure, distinct collagen genes may further aid in the characterization and definition of the development of fibrosis.
- A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress
Summary: A mouse model for renal fibrosis caused by uromodulin mutations reveals roles for ER stress and the unfolded protein response.
- High- and ultrahigh-field magnetic resonance imaging of naïve, injured and scarred vocal fold mucosae in rats
Summary: Magnetic resonance imaging is shown to allow the nondestructive assessment of acute injury and scar formation in vocal fold mucosa, as demonstrated ex vivo using a preclinical rat model.
- Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targeting ex vivo
Drug Discovery Collection: TGFβ induces renal fibrosis in ex vivo cultured precision-cut kidney slices, which can be attenuated by IFNγ.
- Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis
Summary: This study provides clinical and experimental evidence for the different roles played by excess calorie intake in the development of NAFLD and fibrosis; these diseases are dependent on age and reproductive status.
- Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt/β-catenin-driven trans-differentiation of murine alveolar epithelial cells
Summary: The authors identified proteins involved in Wnt/β-catenin-driven alveolar epithelial plasticity in lung injury and repair.