Fibroblasts
- A peek into cancer-associated fibroblasts: origins, functions and translational impact
Summary: Cancer-associated fibroblasts constitute a functionally heterogeneous mesenchymal cell population in the tumor microenvironment. This ‘At a glance’ article reviews their origin and their pro- and antitumor properties.
- Evaluation of human dermal fibroblasts directly reprogrammed to adipocyte-like cells as a metabolic disease model
Summary: Human dermal fibroblasts can be reprogrammed efficiently to adipocyte-like cells that have utility for modelling some aspects of human monogenic metabolic disease.
- Comprehensive analysis of gene expression patterns in Friedreich's ataxia fibroblasts by RNA sequencing reveals altered levels of protein synthesis factors and solute carriers
Summary: Transcriptome profiling of Friedreich's ataxia fibroblasts by RNA sequencing reveals that this peripheral tissue can be used as a disease model for gene expression biomarker discovery.
- Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer
Summary: New insights are provided into the role of hedgehog signaling in maintaining prostate smooth muscle and place hedgehog as a candidate pathway of therapeutic value for treating individuals with prostate cancer.