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Fibroblasts

  • AT A GLANCE
    A peek into cancer-associated fibroblasts: origins, functions and translational impact
    Valerie S. LeBleu, Raghu Kalluri
    Disease Models & Mechanisms 2018 11: dmm029447 doi: 10.1242/dmm.029447 Published 19 April 2018

    Summary: Cancer-associated fibroblasts constitute a functionally heterogeneous mesenchymal cell population in the tumor microenvironment. This ‘At a glance’ article reviews their origin and their pro- and antitumor properties.

  • RESEARCH ARTICLE
    Evaluation of human dermal fibroblasts directly reprogrammed to adipocyte-like cells as a metabolic disease model
    Jian-Hua Chen, Kim Jee Goh, Nuno Rocha, Matthijs P. Groeneveld, Marina Minic, Timothy G. Barrett, David Savage, Robert K. Semple
    Disease Models & Mechanisms 2017 10: 1411-1420; doi: 10.1242/dmm.030981

    Summary: Human dermal fibroblasts can be reprogrammed efficiently to adipocyte-like cells that have utility for modelling some aspects of human monogenic metabolic disease.

  • RESOURCE ARTICLE
    Comprehensive analysis of gene expression patterns in Friedreich's ataxia fibroblasts by RNA sequencing reveals altered levels of protein synthesis factors and solute carriers
    Jill Sergesketter Napierala, Yanjie Li, Yue Lu, Kevin Lin, Lauren A. Hauser, David R. Lynch, Marek Napierala
    Disease Models & Mechanisms 2017 10: 1353-1369; doi: 10.1242/dmm.030536

    Summary: Transcriptome profiling of Friedreich's ataxia fibroblasts by RNA sequencing reveals that this peripheral tissue can be used as a disease model for gene expression biomarker discovery.

  • RESEARCH ARTICLE
    Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer
    Zhaohui Yang, Yu-Ching Peng, Anuradha Gopalan, Dong Gao, Yu Chen, Alexandra L. Joyner
    Disease Models & Mechanisms 2017 10: 39-52; doi: 10.1242/dmm.027417

    Summary: New insights are provided into the role of hedgehog signaling in maintaining prostate smooth muscle and place hedgehog as a candidate pathway of therapeutic value for treating individuals with prostate cancer.

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