Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Subject collections
    • Interviews
    • Sign up for alerts
  • About us
    • About DMM
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Outstanding paper prize
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contact
    • Contact DMM
    • Advertising
    • Feedback
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

User menu

  • Log in

Search

  • Advanced search
Disease Models & Mechanisms
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

supporting biologistsinspiring biology

Disease Models & Mechanisms

Advanced search

RSS   Twitter   Facebook   YouTube

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Subject collections
    • Interviews
    • Sign up for alerts
  • About us
    • About DMM
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Outstanding paper prize
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contact
    • Contact DMM
    • Advertising
    • Feedback

ER stress

  • RESEARCH ARTICLE
    Modulating the endoplasmic reticulum stress response attenuates neurodegeneration in a Caenorhabditis elegans model of spinal muscular atrophy
    James J. Doyle, Celine Vrancx, Claudia Maios, Audrey Labarre, Shunmoogum A. Patten, J. Alex Parker
    Disease Models & Mechanisms 2020 13: dmm041350 doi: 10.1242/dmm.041350 Published 22 December 2020

    Summary: A new non-larval-lethal C. elegans model of spinal muscular atrophy shows mild phenotypes, such as muscle cell and neuronal degeneration, and is therefore useful for testing potential drug treatments.

  • RESEARCH ARTICLE
    Adenoviral TMBIM6 vector attenuates ER-stress-induced apoptosis in a neonatal hypoxic-ischemic rat model
    Desislava Doycheva, Ningbo Xu, Harpreet Kaur, Jay Malaguit, Devin William McBride, Jiping Tang, John H. Zhang
    Disease Models & Mechanisms 2019 12: dmm040352 doi: 10.1242/dmm.040352 Published 22 November 2019

    Summary: Elucidating the role of Bax inhibitor 1 (BI-1) and its mechanisms in the pathophysiology of hypoxic ischemic encephalopathy may help provide a basis for BI-1 as a potential therapeutic target in clinics.

  • RESEARCH ARTICLE
    Differential regulation of the unfolded protein response in outbred deer mice and susceptibility to metabolic disease
    Amanda Havighorst, Youwen Zhang, Elena Farmaki, Vimala Kaza, Ioulia Chatzistamou, Hippokratis Kiaris
    Disease Models & Mechanisms 2019 12: dmm037242 doi: 10.1242/dmm.037242 Published 27 February 2019

    Summary: By using genetically diverse deer mice, we show that the expression of different chaperones is highly coordinated in individual animals and its profile predicts the onset of metabolic pathology.

  • RESEARCH ARTICLE
    A nonalcoholic fatty liver disease model in human induced pluripotent stem cell-derived hepatocytes, created by endoplasmic reticulum stress-induced steatosis
    Maddalena Parafati, R. Jason Kirby, Sepideh Khorasanizadeh, Fraydoon Rastinejad, Siobhan Malany
    Disease Models & Mechanisms 2018 11: dmm033530 doi: 10.1242/dmm.033530 Published 25 September 2018

    Summary: Our study demonstrates expanded use of human induced pluripotent stem cell-derived hepatocytes for molecular studies and drug screening, to evaluate new therapeutics with an antisteatotic mechanism of action for nonalcoholic fatty liver disease.

  • RESEARCH ARTICLE
    A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress
    Sian E. Piret, Eric Olinger, Anita A. C. Reed, M. Andrew Nesbit, Tertius A. Hough, Liz Bentley, Olivier Devuyst, Roger D. Cox, Rajesh V. Thakker
    Disease Models & Mechanisms 2017 10: 773-786; doi: 10.1242/dmm.029488

    Summary: A mouse model for renal fibrosis caused by uromodulin mutations reveals roles for ER stress and the unfolded protein response.

  • RESEARCH ARTICLE
    Vertical sleeve gastrectomy reduces blood pressure and hypothalamic endoplasmic reticulum stress in mice
    Anne K. McGavigan, Zachariah M. Henseler, Darline Garibay, Scott D. Butler, Sisitha Jayasinghe, Ruth E. Ley, Robin L. Davisson, Bethany P. Cummings
    Disease Models & Mechanisms 2017 10: 235-243; doi: 10.1242/dmm.027474

    Summary: Vertical sleeve gastrectomy in mice decreases blood pressure independent of body mass, which may be due to a decrease in hypothalamic ER stress.

  • RESEARCH ARTICLE
    Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish
    Ana M. Vacaru, Antonio Fabio Di Narzo, Deanna L. Howarth, Orkhontuya Tsedensodnom, Dru Imrie, Ayca Cinaroglu, Salma Amin, Ke Hao, Kirsten C. Sadler
    Disease Models & Mechanisms 2014 7: 823-835; doi: 10.1242/dmm.014472
  • RESEARCH ARTICLE
    Complexes of Usher proteins preassemble at the endoplasmic reticulum and are required for trafficking and ER homeostasis
    Bernardo Blanco-Sánchez, Aurélie Clément, Javier Fierro, Jr, Philip Washbourne, Monte Westerfield
    Disease Models & Mechanisms 2014 7: 547-559; doi: 10.1242/dmm.014068
  • RESEARCH ARTICLE
    TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS
    Michelle L. Thompson, Pan Chen, Xiaohui Yan, Hanna Kim, Akeem R. Borom, Nathan B. Roberts, Kim A. Caldwell, Guy A. Caldwell
    Disease Models & Mechanisms 2014 7: 233-243; doi: 10.1242/dmm.013615

Other subject collections

Articles

  • Accepted manuscripts
  • Issue in progress
  • Latest complete issue
  • Issue archive
  • Archive by article type
  • Subject collections
  • Interviews
  • Sign up for alerts

About us

  • About DMM
  • Editors and Board
  • Editor biographies
  • Travelling Fellowships
  • Grants and funding
  • Journal Meetings
  • Workshops
  • The Company of Biologists

For Authors

  • Submit a manuscript
  • Aims and scope
  • Presubmission enquiries
  • Article types
  • Manuscript preparation
  • Cover suggestions
  • Editorial process
  • Promoting your paper
  • Open Access
  • Biology Open transfer

Journal Info

  • Journal policies
  • Rights and permissions
  • Media policies
  • Reviewer guide
  • Sign up for alerts

Contact

  • Contact DMM
  • Advertising
  • Feedback

Twitter   YouTube   LinkedIn

© 2021   The Company of Biologists Ltd   Registered Charity 277992