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eQTL

  • RESEARCH ARTICLE
    Conserved properties of genetic architecture of renal and fat transcriptomes in rat models of insulin resistance
    Georg W. Otto, Pamela J. Kaisaki, Francois Brial, Aurélie Le Lay, Jean-Baptiste Cazier, Richard Mott, Dominique Gauguier
    Disease Models & Mechanisms 2019 12: dmm038539 doi: 10.1242/dmm.038539 Published 15 July 2019

    Summary: Kidney and fat expression QTL mapping in rat models of spontaneously occurring insulin resistance associated with either diabetes or hypertension reveals conserved gene expression regulation, suggesting shared aetiology of disease phenotypes.

  • REVIEW
    From integrative genomics to systems genetics in the rat to link genotypes to phenotypes
    Aida Moreno-Moral, Enrico Petretto
    Disease Models & Mechanisms 2016 9: 1097-1110; doi: 10.1242/dmm.026104

    Summary: This Review describes the most recent advances in the field of systems genetics, focusing on the rat. We cover from the first integrative genomics strategies (such as mapping of expression QTLs or eQTLs) and conclude with the most sophisticated gene network-based analyses in multiple systems and disease states.

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