Epilepsy
- Targeted knockout of GABA-A receptor gamma 2 subunit provokes transient light-induced reflex seizures in zebrafish larvae
Summary: The authors present a novel in vivo genetic model of idiopathic epilepsy in zebrafish (gabrg2−/−) to aid the study of ictogenesis and provide a convenient genetic tool for drug screening.
- A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain
Summary: New phenotypes are revealed by a GLUT1 deficiency mutant mouse model carrying a missense mutation in Glut1.
- Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in Dictyostelium discoideum
Editor's choice: Here, using a tractable model system, Dictyostelium discoideum, we show that diacylglycerol kinase activity might contribute to the cellular mechanism of action of the epilepsy and bipolar disorder treatment, valproic acid.
- Temporal analysis of hippocampal CA3 gene coexpression networks in a rat model of febrile seizures
Summary: We carried out a temporal analysis of hippocampal gene coexpression networks to identify relevant genes in a rat model of hyperthermic seizures. These genes were mostly related to immune response, cell adhesion and neurogenesis.
- Pumilio2-deficient mice show a predisposition for epilepsy
Summary: Epileptogenic risk factors are misregulated in Pumilio2-deficient mice, determining a predisposition to develop seizures. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.
- Seizure control through genetic and pharmacological manipulation of Pumilio in Drosophila: a key component of neuronal homeostasis
Summary: Next-generation anticonvulsant compounds potentiate the activity of the neuronal homeostatic regulator Pumilio.