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Epilepsy

  • REVIEW
    Modelling epilepsy in the mouse: challenges and solutions
    Grant F. Marshall, Alfredo Gonzalez-Sulser, Catherine M. Abbott
    Disease Models & Mechanisms 2021 14: dmm047449 doi: 10.1242/dmm.047449 Published 1 March 2021

    Summary: This Review discusses the challenges of modelling epilepsy in mice, a condition in which the outward manifestation of the disorder appears only sporadically, and reviews possible solutions encompassing both genetic and induced models.

  • RESEARCH ARTICLE
    Targeted knockout of GABA-A receptor gamma 2 subunit provokes transient light-induced reflex seizures in zebrafish larvae
    Meijiang Liao, Uday Kundap, Richard E. Rosch, Dominic R. W. Burrows, Martin P. Meyer, Bouchra Ouled Amar Bencheikh, Patrick Cossette, Éric Samarut
    Disease Models & Mechanisms 2019 12: dmm040782 doi: 10.1242/dmm.040782 Published 11 November 2019

    Summary: The authors present a novel in vivo genetic model of idiopathic epilepsy in zebrafish (gabrg2−/−) to aid the study of ictogenesis and provide a convenient genetic tool for drug screening.

  • RESEARCH ARTICLE
    A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain
    Tamio Furuse, Hiroshi Mizuma, Yuuki Hirose, Tomoko Kushida, Ikuko Yamada, Ikuo Miura, Hiroshi Masuya, Hiromasa Funato, Masashi Yanagisawa, Hirotaka Onoe, Shigeharu Wakana
    Disease Models & Mechanisms 2019 12: dmm038828 doi: 10.1242/dmm.038828 Published 12 September 2019

    Summary: New phenotypes are revealed by a GLUT1 deficiency mutant mouse model carrying a missense mutation in Glut1.

  • RESEARCH ARTICLE
    Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in Dictyostelium discoideum
    Elizabeth Kelly, Devdutt Sharma, Christopher J. Wilkinson, Robin S. B. Williams
    Disease Models & Mechanisms 2018 11: dmm035600 doi: 10.1242/dmm.035600 Published 21 August 2018

    Editor's choice: Here, using a tractable model system, Dictyostelium discoideum, we show that diacylglycerol kinase activity might contribute to the cellular mechanism of action of the epilepsy and bipolar disorder treatment, valproic acid.

  • RESEARCH ARTICLE
    Temporal analysis of hippocampal CA3 gene coexpression networks in a rat model of febrile seizures
    Hatylas Azevedo, Nathália Amato Khaled, Paula Santos, Fernanda Bernardi Bertonha, Carlos Alberto Moreira-Filho
    Disease Models & Mechanisms 2018 11: dmm029074 doi: 10.1242/dmm.029074 Published 29 January 2018

    Summary: We carried out a temporal analysis of hippocampal gene coexpression networks to identify relevant genes in a rat model of hyperthermic seizures. These genes were mostly related to immune response, cell adhesion and neurogenesis.

  • RESEARCH ARTICLE
    Pumilio2-deficient mice show a predisposition for epilepsy
    Philipp Follwaczny, Rico Schieweck, Therese Riedemann, Antonia Demleitner, Tobias Straub, Anna H. Klemm, Martin Bilban, Bernd Sutor, Bastian Popper, Michael A. Kiebler
    Disease Models & Mechanisms 2017 10: 1333-1342; doi: 10.1242/dmm.029678

    Summary: Epileptogenic risk factors are misregulated in Pumilio2-deficient mice, determining a predisposition to develop seizures. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.

  • RESEARCH ARTICLE
    Seizure control through genetic and pharmacological manipulation of Pumilio in Drosophila: a key component of neuronal homeostasis
    Wei-Hsiang Lin, Carlo N. G. Giachello, Richard A. Baines
    Disease Models & Mechanisms 2017 10: 141-150; doi: 10.1242/dmm.027045

    Summary: Next-generation anticonvulsant compounds potentiate the activity of the neuronal homeostatic regulator Pumilio.

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