Drosophila
- Anti-tumour effects of antimicrobial peptides, components of the innate immune system, against haematopoietic tumours in Drosophila mxc mutants
Summary: Antimicrobial peptides can interact with tumour cells generated in a haematopoietic tissue in Drosophila mxc mutants and have a tumour-suppressive effect on their growth.
- Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity
Editor's choice: Using Drosophila as a low-complexity model for human myeloproliferative neoplasms, the authors identified a conserved mechanism by which the Tip60 lysine acetyltransferase acts as a tumor suppressor by repressing JAK protein expression in a histone-independent manner.
- Intellectual disability and autism spectrum disorders ‘on the fly’: insights from Drosophila
Summary: This Review summarizes some of the exciting work that has used Drosophila as a model for the ever-expanding field of intellectual disability and autism spectrum disorders. It highlights disease-relevant assays, emerging themes and future challenges.
- One hundred years of Drosophila cancer research: no longer in solitude
Summary: This Special Article summarises the history of Drosophila as a model to understand the cancer problem, from the initial work carried out by Mary Stark 100 years ago to today.
- Effect of dietary additives on intestinal permeability in both Drosophila and a human cell co-culture
Summary: Sugar and other food additives can inhibit gut barrier function in both human cell co-cultures and Drosophila melanogaster.
- Identification of cardioprotective drugs by medium-scale in vivo pharmacological screening on a Drosophila cardiac model of Friedreich's ataxia
Editor's choice: The first medium-scale pharmacological in vivo screen on a Drosophila cardiac model identified 11 compounds with protective effects on Friedreich's ataxia cardiomyopathy.
- Using Drosophila to study mechanisms of hereditary hearing loss
Summary: This Review discusses the similarities and differences between hearing in mammals and the fruit fly Drosophila, and describes how recent technological developments allow Drosophila to be used as a model to understand the function of human deafness genes.
- Bruno-3 regulates sarcomere component expression and contributes to muscle phenotypes of myotonic dystrophy type 1
Summary: Our data suggest that, the so far ignored, cytoplasmic Bru-3/CELF1 contributes to myotonic dystrophy type 1 pathogenesis in a Drosophila model by regulating sarcomeric transcripts and protein levels.
- Drosophila Insulin receptor regulates the persistence of injury-induced nociceptive sensitization
Summary: Drosophila insulin signaling is required within nociceptive sensory neurons to regulate the persistence of thermal pain sensitization. We describe a model that could be useful to dissect diabetes-induced pain syndromes.
- Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotonic dystrophy
Summary: MBNL protein sequestration by expanded CUG RNA contributes towards cardiac dysfunction in a myotonic dystrophy Drosophila model. Here, the authors identify the anticancer drug daunorubicin as a candidate therapeutic for the disease.