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Drosophila

  • RESEARCH ARTICLE
    Mistargeting of secretory cargo in retromer-deficient cells
    Sarah D. Neuman, Erica L. Terry, Jane E. Selegue, Amy T. Cavanagh, Arash Bashirullah
    Disease Models & Mechanisms 2021 14: dmm046417 doi: 10.1242/dmm.046417 Published 22 January 2021

    Summary: Using Drosophila larval salivary glands as a model system, we show a new role for retromer in trafficking of secretory membrane and cargo proteins during regulated exocytosis, which could be relevant in neurodegenerative diseases.

  • RESEARCH ARTICLE
    Loss of the Drosophila branched-chain α-ketoacid dehydrogenase complex results in neuronal dysfunction
    Hui-Ying Tsai, Shih-Cheng Wu, Jian-Chiuan Li, Yu-Min Chen, Chih-Chiang Chan, Chun-Hong Chen
    Disease Models & Mechanisms 2020 13: dmm044750 doi: 10.1242/dmm.044750 Published 27 August 2020

    Summary: Loss of BCKDH activity in Drosophila recapitulates the neurological symptoms of patients with maple syrup urine disease. Metformin administration was found to alleviate developmental defects and aberrant behavior in the BCKDH mutant.

  • RESEARCH ARTICLE
    A Drosophila model of oral peptide therapeutics for adult intestinal stem cell tumors
    Anjali Bajpai, Taushif Ahmad Quazi, Hong-Wen Tang, Nishat Manzar, Virender Singh, Ashwani Thakur, Bushra Ateeq, Norbert Perrimon, Pradip Sinha
    Disease Models & Mechanisms 2020 13: dmm044420 doi: 10.1242/dmm.044420 Published 23 July 2020

    Summary: We demonstrate that, when fed to flies, TONDU peptide suppresses Yki-driven intestinal stem cell (ISC) tumors, and identify integrins as essential components of ISC tumorigenesis.

  • REVIEW
    Temporal patterning in neural progenitors: from Drosophila development to childhood cancers
    Cédric Maurange
    Disease Models & Mechanisms 2020 13: dmm044883 doi: 10.1242/dmm.044883 Published 22 July 2020

    Summary: Temporal patterning is the mechanism by which neural progenitors change their competence and proliferative properties during development. Recent data suggest that co-opted temporal patterning could govern tumor growth in neural cancers with developmental origins.

  • RESEARCH ARTICLE
    A Drosophila model to study retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8
    Dimitrije Stanković, Ann-Katrin Claudius, Thomas Schertel, Tina Bresser, Mirka Uhlirova
    Disease Models & Mechanisms 2020 13: dmm043174 doi: 10.1242/dmm.043174 Published 26 June 2020

    Summary: A Drosophila melanogaster disease model of retinitis pigmentosa type 13 to study the mechanisms underlying the loss of tissue homeostasis and degeneration caused by mutations in the core component of the spliceosome Prp8.

  • RESEARCH ARTICLE
    Zika virus non-structural protein NS4A restricts eye growth in Drosophila through regulation of JAK/STAT signaling
    Sneh Harsh, Yulong Fu, Eric Kenney, Zhe Han, Ioannis Eleftherianos
    Disease Models & Mechanisms 2020 13: dmm040816 doi: 10.1242/dmm.040816 Published 30 April 2020

    Summary: Our study provides evidence that Zika virus infection in Drosophila results in restricted growth of the developing eye and wing through regulation of JAK/STAT and Notch signaling, respectively.

  • RESEARCH ARTICLE
    Anti-tumour effects of antimicrobial peptides, components of the innate immune system, against haematopoietic tumours in Drosophila mxc mutants
    Mayo Araki, Massanori Kurihara, Suzuko Kinoshita, Rie Awane, Tetsuya Sato, Yasuyuki Ohkawa, Yoshihiro H. Inoue
    Disease Models & Mechanisms 2019 12: dmm037721 doi: 10.1242/dmm.037721 Published 18 June 2019

    Summary: Antimicrobial peptides can interact with tumour cells generated in a haematopoietic tissue in Drosophila mxc mutants and have a tumour-suppressive effect on their growth.

  • RESEARCH ARTICLE
    Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity
    Alessandro A. Bailetti, Lenny J. Negrón-Piñeiro, Vishal Dhruva, Sneh Harsh, Sean Lu, Aisha Bosula, Erika A. Bach
    Disease Models & Mechanisms 2019 12: dmm038679 doi: 10.1242/dmm.038679 Published 30 May 2019

    Editor's choice: Using Drosophila as a low-complexity model for human myeloproliferative neoplasms, the authors identified a conserved mechanism by which the Tip60 lysine acetyltransferase acts as a tumor suppressor by repressing JAK protein expression in a histone-independent manner.

  • REVIEW
    Intellectual disability and autism spectrum disorders ‘on the fly’: insights from Drosophila
    Mireia Coll-Tané, Alina Krebbers, Anna Castells-Nobau, Christiane Zweier, Annette Schenck
    Disease Models & Mechanisms 2019 12: dmm039180 doi: 10.1242/dmm.039180 Published 13 May 2019

    Summary: This Review summarizes some of the exciting work that has used Drosophila as a model for the ever-expanding field of intellectual disability and autism spectrum disorders. It highlights disease-relevant assays, emerging themes and future challenges.

  • SPECIAL ARTICLE
    One hundred years of Drosophila cancer research: no longer in solitude
    Santiago Nahuel Villegas
    Disease Models & Mechanisms 2019 12: dmm039032 doi: 10.1242/dmm.039032 Published 1 April 2019

    Summary: This Special Article summarises the history of Drosophila as a model to understand the cancer problem, from the initial work carried out by Mary Stark 100 years ago to today.

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