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Disuse

  • RESEARCH ARTICLE
    Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas
    María Gabriela Morales, Johanna Abrigo, María José Acuña, Robson A. Santos, Michael Bader, Enrique Brandan, Felipe Simon, Hugo Olguin, Daniel Cabrera, Claudio Cabello-Verrugio
    Disease Models & Mechanisms 2016 9: 441-449; doi: 10.1242/dmm.023390

    Summary: In this article, the authors demonstrate that a peptide with actions mainly in the cardiovascular system prevents the skeletal muscle damage induced by disuse.

  • RESEARCH ARTICLE
    The role of mTOR signaling in the regulation of protein synthesis and muscle mass during immobilization in mice
    Jae-Sung You, Garrett B. Anderson, Matthew S. Dooley, Troy A. Hornberger
    Disease Models & Mechanisms 2015 8: 1059-1069; doi: 10.1242/dmm.019414

    Summary: The activation of mTOR signaling is both necessary and sufficient to alleviate the decreases in protein synthesis and muscle mass that occur during immobilization.

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