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Disease

  • AT A GLANCE
    Membrane trafficking in health and disease
    Rebecca Yarwood, John Hellicar, Philip G. Woodman, Martin Lowe
    Disease Models & Mechanisms 2020 13: dmm043448 doi: 10.1242/dmm.043448 Published 30 April 2020

    Summary: This At a Glance article and poster summarise the major intracellular membrane trafficking pathways and associated molecular machineries, and describe how defects in these give rise to disease in humans.

  • A MODEL FOR LIFE
    Of oncogenes and open science: an interview with Harold Varmus
    Harold Varmus
    Disease Models & Mechanisms 2019 12: dmm038919 doi: 10.1242/dmm.038919 Published 1 March 2019
  • REVIEW
    Dissecting human disease with single-cell omics: application in model systems and in the clinic
    Paulina M. Strzelecka, Anna M. Ranzoni, Ana Cvejic
    Disease Models & Mechanisms 2018 11: dmm036525 doi: 10.1242/dmm.036525 Published 5 November 2018

    Summary: This Review summarises the current state of the art of single-cell techniques and their potential applications in deciphering the heterogeneous nature of diseases and tailoring personalised therapies.

  • AT A GLANCE
    RNA metabolism in neurodegenerative disease
    Elaine Y. Liu, Christopher P. Cali, Edward B. Lee
    Disease Models & Mechanisms 2017 10: 509-518; doi: 10.1242/dmm.028613

    Summary: In this At a Glance review, Edward Lee and co-authors provide an overview of RNA metabolism defects, including mislocalization of RNA-binding proteins and microRNA biogenesis alterations, that contribute to neurodegenerative disease pathology.

  • SPECIAL ARTICLE
    Exploring human disease using the Rat Genome Database
    Mary Shimoyama, Stanley J. F. Laulederkind, Jeff De Pons, Rajni Nigam, Jennifer R. Smith, Marek Tutaj, Victoria Petri, G. Thomas Hayman, Shur-Jen Wang, Omid Ghiasvand, Jyothi Thota, Melinda R. Dwinell
    Disease Models & Mechanisms 2016 9: 1089-1095; doi: 10.1242/dmm.026021

    Summary: The Rat Genome Database (RGD) is the most comprehensive site for genetic, genomic and phenotype data for Rattus norvegicus, a leading animal model for disease-, drug- and toxicity-related research.

  • REVIEW
    Telomeres in aging and disease: lessons from zebrafish
    Madalena C. Carneiro, InĂªs Pimenta de Castro, Miguel Godinho Ferreira
    Disease Models & Mechanisms 2016 9: 737-748; doi: 10.1242/dmm.025130

    Summary: In this Review, the authors explore the advantages of using zebrafish in telomere research and discuss the primary discoveries made in this model that have contributed to expanding our knowledge of how telomere attrition contributes to cellular senescence, organ dysfunction and disease.

  • RESEARCH ARTICLE
    A Drosophila model for mito-nuclear diseases generated by an incompatible interaction between tRNA and tRNA synthetase
    Marissa A. Holmbeck, Julia R. Donner, Eugenia Villa-Cuesta, David M. Rand
    Disease Models & Mechanisms 2015 8: 843-854; doi: 10.1242/dmm.019323

    Summary: Interacting mutations in a mitochondrially encoded tRNA and nuclear-encoded tRNA synthetase result in a suite of pathologies, including altered locomotor capacity, mitochondrial function and morphology, and mitochondrial translation.

  • REVIEW
    Aneuploidy: implications for protein homeostasis and disease
    Ana B. Oromendia, Angelika Amon
    Disease Models & Mechanisms 2014 7: 15-20; doi: 10.1242/dmm.013391
  • AT A GLANCE
    Mechanisms of protein-folding diseases at a glance
    Julie S. Valastyan, Susan Lindquist
    Disease Models & Mechanisms 2014 7: 9-14; doi: 10.1242/dmm.013474

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