Disease
- Dissecting human disease with single-cell omics: application in model systems and in the clinic
Summary: This Review summarises the current state of the art of single-cell techniques and their potential applications in deciphering the heterogeneous nature of diseases and tailoring personalised therapies.
- RNA metabolism in neurodegenerative disease
Summary: In this At a Glance review, Edward Lee and co-authors provide an overview of RNA metabolism defects, including mislocalization of RNA-binding proteins and microRNA biogenesis alterations, that contribute to neurodegenerative disease pathology.
- Exploring human disease using the Rat Genome Database
Summary: The Rat Genome Database (RGD) is the most comprehensive site for genetic, genomic and phenotype data for Rattus norvegicus, a leading animal model for disease-, drug- and toxicity-related research.
- Telomeres in aging and disease: lessons from zebrafish
Summary: In this Review, the authors explore the advantages of using zebrafish in telomere research and discuss the primary discoveries made in this model that have contributed to expanding our knowledge of how telomere attrition contributes to cellular senescence, organ dysfunction and disease.
- A Drosophila model for mito-nuclear diseases generated by an incompatible interaction between tRNA and tRNA synthetase
Summary: Interacting mutations in a mitochondrially encoded tRNA and nuclear-encoded tRNA synthetase result in a suite of pathologies, including altered locomotor capacity, mitochondrial function and morphology, and mitochondrial translation.