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Dictyostelium discoideum

  • RESEARCH ARTICLE
    Expression of N471D strumpellin leads to defects in the endolysosomal system
    Lin Song, Ramesh Rijal, Malte Karow, Maria Stumpf, Oliver Hahn, Laura Park, Robert Insall, Rolf Schröder, Andreas Hofmann, Christoph S. Clemen, Ludwig Eichinger
    Disease Models & Mechanisms 2018 11: dmm033449 doi: 10.1242/dmm.033449 Published 13 September 2018

    Summary: Strumpellin, a core member of the WASH complex, plays a key role in the endolysosomal system. Deficiencies in endo-/exocytosis and lysosome morphology are caused by the N471D strumpellin mutation, which is associated with spastic paraplegia 8.

  • RESEARCH ARTICLE
    Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in Dictyostelium discoideum
    Elizabeth Kelly, Devdutt Sharma, Christopher J. Wilkinson, Robin S. B. Williams
    Disease Models & Mechanisms 2018 11: dmm035600 doi: 10.1242/dmm.035600 Published 21 August 2018

    Editor's choice: Here, using a tractable model system, Dictyostelium discoideum, we show that diacylglycerol kinase activity might contribute to the cellular mechanism of action of the epilepsy and bipolar disorder treatment, valproic acid.

  • RESEARCH ARTICLE
    Curcumin and derivatives function through protein phosphatase 2A and presenilin orthologues in Dictyostelium discoideum
    Marco Cocorocchio, Amy J. Baldwin, Balint Stewart, Lou Kim, Adrian J. Harwood, Christopher R. L. Thompson, Paul L. R. Andrews, Robin S. B. Williams
    Disease Models & Mechanisms 2018 11: dmm032375 doi: 10.1242/dmm.032375 Published 29 January 2018

    Summary: To unlock the therapeutic potential of curcumin and related compounds, we employ a tractable model system to characterise their cellular and molecular effects and propose novel targets implicated in disease.

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