Dictyostelium discoideum
- Expression of N471D strumpellin leads to defects in the endolysosomal system
Summary: Strumpellin, a core member of the WASH complex, plays a key role in the endolysosomal system. Deficiencies in endo-/exocytosis and lysosome morphology are caused by the N471D strumpellin mutation, which is associated with spastic paraplegia 8.
- Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in Dictyostelium discoideum
Editor's choice: Here, using a tractable model system, Dictyostelium discoideum, we show that diacylglycerol kinase activity might contribute to the cellular mechanism of action of the epilepsy and bipolar disorder treatment, valproic acid.
- Curcumin and derivatives function through protein phosphatase 2A and presenilin orthologues in Dictyostelium discoideum
Summary: To unlock the therapeutic potential of curcumin and related compounds, we employ a tractable model system to characterise their cellular and molecular effects and propose novel targets implicated in disease.