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Danio rerio

  • RESEARCH ARTICLE
    Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish
    Yonghe Ding, Alexey V. Dvornikov, Xiao Ma, Hong Zhang, Yong Wang, Matthew Lowerison, Rene R. Packard, Lei Wang, Jun Chen, Yuji Zhang, Tzung Hsiai, Xueying Lin, Xiaolei Xu
    Disease Models & Mechanisms 2019 12: dmm040154 doi: 10.1242/dmm.040154 Published 1 October 2019

    Summary: This study shows that adult bag3 knockout mutant zebrafish can be used as a model for DCM, and haploinsufficiency of mTOR is cardioprotective.

  • RESEARCH ARTICLE
    Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish
    Gianluca D'Agati, Elena MarĂ­a Cabello, Karl Frontzek, Elisabeth J. Rushing, Robin Klemm, Mark D. Robinson, Richard M. White, Christian Mosimann, Alexa Burger
    Disease Models & Mechanisms 2019 12: dmm039545 doi: 10.1242/dmm.039545 Published 16 July 2019

    Summary: An injection-based chordoma model in zebrafish shows that the hypothesized chordoma oncogene brachyury is insufficient, whereas EGFR and VEGFR2 are sufficient, to trigger notochord hyperplasia in our model.

  • RESEARCH ARTICLE
    A zebrafish larval model reveals early tissue-specific innate immune responses to Mucor circinelloides
    Kerstin Voelz, Remi L. Gratacap, Robert T. Wheeler
    Disease Models & Mechanisms 2015 8: 1375-1388; doi: 10.1242/dmm.019992

    Summary: We use zebrafish larval models to delineate the temporospatial patterns of innate immune responses to fungal infections with mucormycete spores.

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