Danio rerio
- Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish
Summary: This study shows that adult bag3 knockout mutant zebrafish can be used as a model for DCM, and haploinsufficiency of mTOR is cardioprotective.
- Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish
Summary: An injection-based chordoma model in zebrafish shows that the hypothesized chordoma oncogene brachyury is insufficient, whereas EGFR and VEGFR2 are sufficient, to trigger notochord hyperplasia in our model.
- A zebrafish larval model reveals early tissue-specific innate immune responses to Mucor circinelloides
Summary: We use zebrafish larval models to delineate the temporospatial patterns of innate immune responses to fungal infections with mucormycete spores.