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Cytokines

  • RESOURCE ARTICLE
    A novel Cre-enabled tetracycline-inducible transgenic system for tissue-specific cytokine expression in the zebrafish: CETI-PIC3
    Sara Ibrahim, Arianna Harris-Kawano, Isra Haider, Raghavendra G. Mirmira, Emily K. Sims, Ryan M. Anderson
    Disease Models & Mechanisms 2020 13: dmm042556 doi: 10.1242/dmm.042556 Published 26 June 2020

    Summary: Here, we report a novel transgenic zebrafish system that permits tissue-specific, inducible and tunable expression of pro-inflammatory cytokines for modeling inflammatory diseases.

  • RESEARCH ARTICLE
    Leptin and fractalkine: novel subcutaneous cytokines in burn injury
    Dominic Friston, Sini Junttila, Julia Borges Paes Lemes, Helen Laycock, Jose Vicente Torres-Perez, Elizabeth Want, Attila Gyenesei, Istvan Nagy
    Disease Models & Mechanisms 2020 13: dmm042713 doi: 10.1242/dmm.042713 Published 29 April 2020

    Summary: Burn injury is associated with increased levels of leptin and fractalkine in the skin. Signalling by these cytokines leads to macrophage accumulation and hypersensitivity to heat and mechanical stimuli.

  • RESEARCH ARTICLE
    Mast cells enhance sterile inflammation in chronic nonbacterial osteomyelitis
    Stephanie Young, Namit Sharma, Jae Hoon Lee, Violeta Chitu, Volker Neumeister, Elisabeth Sohr, E. Richard Stanley, Christian M. Hedrich, Andrew W. B. Craig
    Disease Models & Mechanisms 2019 12: dmm040097 doi: 10.1242/dmm.040097 Published 20 August 2019

    Summary: This paper reports that mast cells promote bone loss in an autoinflammatory disease model and that mast cell mediators were detected in autoinflammatory disease patient samples.

  • RESEARCH ARTICLE
    Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis
    Thean S. Chew, Nuala R. O'Shea, Gavin W. Sewell, Stefan H. Oehlers, Claire M. Mulvey, Philip S. Crosier, Jasminka Godovac-Zimmermann, Stuart L. Bloom, Andrew M. Smith, Anthony W. Segal
    Disease Models & Mechanisms 2015 8: 817-829; doi: 10.1242/dmm.020362

    Summary: Optineurin plays a role in acute inflammation, proinflammatory cytokine secretion and neutrophil recruitment, which suggests that diminished optineurin expression in humans might increase the risk of developing Crohn's disease.

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