Cytokines
- A novel Cre-enabled tetracycline-inducible transgenic system for tissue-specific cytokine expression in the zebrafish: CETI-PIC3
Summary: Here, we report a novel transgenic zebrafish system that permits tissue-specific, inducible and tunable expression of pro-inflammatory cytokines for modeling inflammatory diseases.
- Leptin and fractalkine: novel subcutaneous cytokines in burn injury
Summary: Burn injury is associated with increased levels of leptin and fractalkine in the skin. Signalling by these cytokines leads to macrophage accumulation and hypersensitivity to heat and mechanical stimuli.
- Mast cells enhance sterile inflammation in chronic nonbacterial osteomyelitis
Summary: This paper reports that mast cells promote bone loss in an autoinflammatory disease model and that mast cell mediators were detected in autoinflammatory disease patient samples.
- Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis
Summary: Optineurin plays a role in acute inflammation, proinflammatory cytokine secretion and neutrophil recruitment, which suggests that diminished optineurin expression in humans might increase the risk of developing Crohn's disease.