Cre recombination
- Generation of brain tumours in mice by Cre-mediated recombination of neural progenitors in situ with the tamoxifen metabolite endoxifen
Summary: An active tamoxifen derivative can be used for the in vivo induction of recombination in situ in mice by CreERT2. We show how this method can be used to generate brain tumours through recombination of tumour suppressor genes in the subventricular zone.