Collagen
- Collagen COL22A1 maintains vascular stability and mutations in COL22A1 are potentially associated with intracranial aneurysms
Summary: Collagen COL22A1 is expressed in perivascular fibroblast-like cells and is required to maintain vascular stability in a zebrafish model. Mutations in COL22A1 are likely to be associated with intracranial aneurysms.
- Use of sodium 4-phenylbutyrate to define therapeutic parameters for reducing intracerebral hemorrhage and myopathy in Col4a1 mutant mice
Summary: COL4A1 mutations cause a multisystem disorder by impairing secretion of COL4A1/A2 heterotrimers. We define parameters for reducing stroke and myopathy in Col4a1 mutant mice by pharmacologically promoting heterotrimer secretion.
- Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis
Summary: Transforming growth factor-β-induced collagen remodelling is driven by enhanced lysyl oxidase expression in idiopathic pulmonary fibrosis.
- Upregulation of distinct collagen transcripts in post-surgery scar tissue: a study of conjunctival fibrosis
Summary: As well as providing an objective quantitative measure, distinct collagen genes may further aid in the characterization and definition of the development of fibrosis.
- Regulation of mitochondrial oxidative stress by β-arrestins in cultured human cardiac fibroblasts
Summary: β-arrestins regulate oxidative stress in a Nox4-dependent manner leading to increased extracellular-matrix protein synthesis by cardiac fibroblasts (CFs). Targeted inhibition of β-arrestins in CFs might decrease pathological fibrosis.
- The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection
Summary: This article describes newly identified intricacies for the TGFβ-ALK5 signalling axis in experimental lung fibrosis and reports different outcomes in response to ALK5 inhibition depending on the presence of viral infection. These findings raise important considerations for the future targeting of TGFβ signalling responses in the context of pulmonary fibrosis.