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Collagen

  • RESOURCE ARTICLE
    Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition
    Aikta Sharma, Alice Goring, Peter B. Johnson, Roger J. H. Emery, Eric Hesse, Alan Boyde, Bjorn R. Olsen, Andrew A. Pitsillides, Richard O. C. Oreffo, Sumeet Mahajan, Claire E. Clarkin
    Disease Models & Mechanisms 2021 : dmm.048116 doi: 10.1242/dmm.048116 Published 9 February 2021
  • RESEARCH ARTICLE
    Collagen COL22A1 maintains vascular stability and mutations in COL22A1 are potentially associated with intracranial aneurysms
    Quynh V. Ton, Daniel Leino, Sarah A. Mowery, Nina O. Bredemeier, Pascal J. Lafontant, Allison Lubert, Suman Gurung, Janice L. Farlow, Tatiana M. Foroud, Joseph Broderick, Saulius Sumanas
    Disease Models & Mechanisms 2018 11: dmm033654 doi: 10.1242/dmm.033654 Published 12 December 2018

    Summary: Collagen COL22A1 is expressed in perivascular fibroblast-like cells and is required to maintain vascular stability in a zebrafish model. Mutations in COL22A1 are likely to be associated with intracranial aneurysms.

  • RESEARCH ARTICLE
    Use of sodium 4-phenylbutyrate to define therapeutic parameters for reducing intracerebral hemorrhage and myopathy in Col4a1 mutant mice
    Genki Hayashi, Cassandre Labelle-Dumais, Douglas B. Gould
    Disease Models & Mechanisms 2018 11: dmm034157 doi: 10.1242/dmm.034157 Published 4 July 2018

    Summary: COL4A1 mutations cause a multisystem disorder by impairing secretion of COL4A1/A2 heterotrimers. We define parameters for reducing stroke and myopathy in Col4a1 mutant mice by pharmacologically promoting heterotrimer secretion.

  • RESEARCH ARTICLE
    Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis
    Gavin Tjin, Eric S. White, Alen Faiz, Delphine Sicard, Daniel J. Tschumperlin, Annabelle Mahar, Eleanor P. W. Kable, Janette K. Burgess
    Disease Models & Mechanisms 2017 10: 1301-1312; doi: 10.1242/dmm.030114

    Summary: Transforming growth factor-β-induced collagen remodelling is driven by enhanced lysyl oxidase expression in idiopathic pulmonary fibrosis.

  • RESEARCH ARTICLE
    Upregulation of distinct collagen transcripts in post-surgery scar tissue: a study of conjunctival fibrosis
    Li-Fong Seet, Li Zhen Toh, Stephanie W. L. Chu, Sharon N. Finger, Jocelyn L. L. Chua, Tina T. Wong
    Disease Models & Mechanisms 2017 10: 751-760; doi: 10.1242/dmm.028555

    Summary: As well as providing an objective quantitative measure, distinct collagen genes may further aid in the characterization and definition of the development of fibrosis.

  • RESEARCH ARTICLE
    Regulation of mitochondrial oxidative stress by β-arrestins in cultured human cardiac fibroblasts
    Jennifer L. Philip, Md. Abdur Razzaque, Mei Han, Jinju Li, Tiju Theccanat, Xianyao Xu, Shahab A. Akhter
    Disease Models & Mechanisms 2015 8: 1579-1589; doi: 10.1242/dmm.019968

    Summary: β-arrestins regulate oxidative stress in a Nox4-dependent manner leading to increased extracellular-matrix protein synthesis by cardiac fibroblasts (CFs). Targeted inhibition of β-arrestins in CFs might decrease pathological fibrosis.

  • RESEARCH ARTICLE
    The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection
    Natalia Smoktunowicz, Robert E. Alexander, Linda Franklin, Andrew E. Williams, Beverley Holman, Paul F. Mercer, Gabor Jarai, Chris J. Scotton, Rachel C. Chambers
    Disease Models & Mechanisms 2015 8: 1129-1139; doi: 10.1242/dmm.019984

    Summary: This article describes newly identified intricacies for the TGFβ-ALK5 signalling axis in experimental lung fibrosis and reports different outcomes in response to ALK5 inhibition depending on the presence of viral infection. These findings raise important considerations for the future targeting of TGFβ signalling responses in the context of pulmonary fibrosis.

  • REVIEWS
    Diverse functions of matrix metalloproteinases during fibrosis
    Matthew Giannandrea, William C. Parks
    Disease Models & Mechanisms 2014 7: 193-203; doi: 10.1242/dmm.012062

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