Central nervous system
- Experimental models and tools to tackle glioblastoma
Summary: This Review discusses preclinical modelling of glioblastoma multiforme to understand its biology and develop therapies, with a focus on mammalian model systems.
- Collagen VI in healthy and diseased nervous system
Summary: Although collagen VI was so far known to be mostly involved in skeletal muscle homeostasis, this Review summarizes a number of recent studies that highlight its key role in the peripheral and central nervous systems, pointing at a link with human neurological disorders.
- Imaging of viral neuroinvasion in the zebrafish reveals that Sindbis and chikungunya viruses favour different entry routes
Summary: Imaging of neuroinvasion in zebrafish shows that chikungunya virus first infects the blood-brain barrier, whereas Sindbis virus relies on axonal transport.
- Mosaic expression of Atrx in the mouse central nervous system causes memory deficits
Summary: Heterozygous expression of the X-linked gene Atrx in the mouse brain causes deficits in spatial, contextual fear and object recognition memory.
- Identification of gene expression patterns crucially involved in experimental autoimmune encephalomyelitis and multiple sclerosis
Summary: To define disease-inducing immune responses, unbiased gene expression in LEW.1AV1 (RT1av1) rats immunized with autoantigen-derived encephalitogenic and non-encephalitogenic peptides was investigated in MOG-EAE. CXCR4, CXCL12, AKT and CD38 control CNS inflammation.