Cancer
- The SDHB Arg230His mutation causing familial paraganglioma alters glycolysis in a new Caenorhabditis elegans model
Editor’s choice: Heritable pheochromocytoma/paraganglioma follows the Arg230His missense mutation in SDHB in mitochondrial complex II. By mutating this highly conserved ortholog in C. elegans, we generated a tractable phenotype.
- Spz/Toll-6 signal guides organotropic metastasis in Drosophila
Summary: The authors report Toll-6 and Spätzle as a new pair of guidance molecules mediating organ-specific metastasis behavior by activating JNK signaling, highlighting a novel role for Toll-family receptors.
- Experimental models and tools to tackle glioblastoma
Summary: This Review discusses preclinical modelling of glioblastoma multiforme to understand its biology and develop therapies, with a focus on mammalian model systems.
- Photoacoustic imaging as a tool to probe the tumour microenvironment
Summary: This Review details the potential of photoacoustic imaging to visualise features of the tumour microenvironment such as blood vessels, hypoxia, fibrosis and immune infiltrate to provide unprecedented insight into tumour biology.
- Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish
Summary: An injection-based chordoma model in zebrafish shows that the hypothesized chordoma oncogene brachyury is insufficient, whereas EGFR and VEGFR2 are sufficient, to trigger notochord hyperplasia in our model.
- One hundred years of Drosophila cancer research: no longer in solitude
Summary: This Special Article summarises the history of Drosophila as a model to understand the cancer problem, from the initial work carried out by Mary Stark 100 years ago to today.
- The secret lives of cancer cell lines
Summary: A recent study in Nature demonstrated that ongoing mutational processes cause significant heterogeneity of widely used cancer cell lines. In this Editorial, the authors discuss the implications of these findings for the cancer and cell biology fields.
- Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ)
Summary: Here, we developed Transgene Electroporation in Adult Zebrafish (TEAZ), a method that enables researchers to study cancer and metastasis by introducing DNA elements focally into somatic adult tissue.