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Cancer

  • RESEARCH ARTICLE
    Heterogeneity in clone dynamics within and adjacent to intestinal tumours identified by Dre-mediated lineage tracing
    Ann-Sofie Thorsen, Doran Khamis, Richard Kemp, Mathilde Colombé, Filipe C. Lourenço, Edward Morrissey, Douglas Winton
    Disease Models & Mechanisms 2021 14: dmm046706 doi: 10.1242/dmm.046706 Published 15 January 2021

    Summary: A novel DrePr recombinase used for sequential lineage tracing in mouse intestinal tissue identifies clonal heterogeneity within tumours, and impaired clonal dynamics in adjacent epithelia may promote tumour growth.

  • RESEARCH ARTICLE
    The SDHB Arg230His mutation causing familial paraganglioma alters glycolysis in a new Caenorhabditis elegans model
    Éva Saskői, Zoltán Hujber, Gábor Nyírő, István Likó, Barbara Mátyási, Gábor Petővári, Katalin Mészáros, Attila L. Kovács, László Patthy, Shreyas Supekar, Hao Fan, Gergely Sváb, László Tretter, Arunabh Sarkar, Aamir Nazir, Anna Sebestyén, Attila Patócs, Anil Mehta, Krisztina Takács-Vellai
    Disease Models & Mechanisms 2020 13: dmm044925 doi: 10.1242/dmm.044925 Published 15 October 2020

    Editor’s choice: Heritable pheochromocytoma/paraganglioma follows the Arg230His missense mutation in SDHB in mitochondrial complex II. By mutating this highly conserved ortholog in C. elegans, we generated a tractable phenotype.

  • RESEARCH ARTICLE
    Spz/Toll-6 signal guides organotropic metastasis in Drosophila
    Ketu Mishra-Gorur, Daming Li, Xianjue Ma, Yanki Yarman, Lei Xue, Tian Xu
    Disease Models & Mechanisms 2019 12: dmm039727 doi: 10.1242/dmm.039727 Published 7 October 2019

    Summary: The authors report Toll-6 and Spätzle as a new pair of guidance molecules mediating organ-specific metastasis behavior by activating JNK signaling, highlighting a novel role for Toll-family receptors.

  • REVIEW
    Experimental models and tools to tackle glioblastoma
    Faye L. Robertson, Maria-Angeles Marqués-Torrejón, Gillian M. Morrison, Steven M. Pollard
    Disease Models & Mechanisms 2019 12: dmm040386 doi: 10.1242/dmm.040386 Published 6 September 2019

    Summary: This Review discusses preclinical modelling of glioblastoma multiforme to understand its biology and develop therapies, with a focus on mammalian model systems.

  • REVIEW
    Photoacoustic imaging as a tool to probe the tumour microenvironment
    Emma Brown, Joanna Brunker, Sarah E. Bohndiek
    Disease Models & Mechanisms 2019 12: dmm039636 doi: 10.1242/dmm.039636 Published 16 July 2019

    Summary: This Review details the potential of photoacoustic imaging to visualise features of the tumour microenvironment such as blood vessels, hypoxia, fibrosis and immune infiltrate to provide unprecedented insight into tumour biology.

  • RESEARCH ARTICLE
    Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish
    Gianluca D'Agati, Elena María Cabello, Karl Frontzek, Elisabeth J. Rushing, Robin Klemm, Mark D. Robinson, Richard M. White, Christian Mosimann, Alexa Burger
    Disease Models & Mechanisms 2019 12: dmm039545 doi: 10.1242/dmm.039545 Published 16 July 2019

    Summary: An injection-based chordoma model in zebrafish shows that the hypothesized chordoma oncogene brachyury is insufficient, whereas EGFR and VEGFR2 are sufficient, to trigger notochord hyperplasia in our model.

  • SPECIAL ARTICLE
    One hundred years of Drosophila cancer research: no longer in solitude
    Santiago Nahuel Villegas
    Disease Models & Mechanisms 2019 12: dmm039032 doi: 10.1242/dmm.039032 Published 1 April 2019

    Summary: This Special Article summarises the history of Drosophila as a model to understand the cancer problem, from the initial work carried out by Mary Stark 100 years ago to today.

  • A MODEL FOR LIFE
    Of oncogenes and open science: an interview with Harold Varmus
    Harold Varmus
    Disease Models & Mechanisms 2019 12: dmm038919 doi: 10.1242/dmm.038919 Published 1 March 2019
  • EDITORIAL
    The secret lives of cancer cell lines
    Robert E. Hynds, Elina Vladimirou, Sam. M. Janes
    Disease Models & Mechanisms 2018 11: dmm037366 doi: 10.1242/dmm.037366 Published 16 November 2018

    Summary: A recent study in Nature demonstrated that ongoing mutational processes cause significant heterogeneity of widely used cancer cell lines. In this Editorial, the authors discuss the implications of these findings for the cancer and cell biology fields.

  • RESOURCE ARTICLE
    Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ)
    Scott J. Callahan, Stephanie Tepan, Yan M. Zhang, Helen Lindsay, Alexa Burger, Nathaniel R. Campbell, Isabella S. Kim, Travis J. Hollmann, Lorenz Studer, Christian Mosimann, Richard M. White
    Disease Models & Mechanisms 2018 11: dmm034561 doi: 10.1242/dmm.034561 Published 27 September 2018

    Summary: Here, we developed Transgene Electroporation in Adult Zebrafish (TEAZ), a method that enables researchers to study cancer and metastasis by introducing DNA elements focally into somatic adult tissue.

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