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Caenorhabditis elegans

  • RESEARCH ARTICLE
    Modulating the endoplasmic reticulum stress response attenuates neurodegeneration in a Caenorhabditis elegans model of spinal muscular atrophy
    James J. Doyle, Celine Vrancx, Claudia Maios, Audrey Labarre, Shunmoogum A. Patten, J. Alex Parker
    Disease Models & Mechanisms 2020 13: dmm041350 doi: 10.1242/dmm.041350 Published 22 December 2020

    Summary: A new non-larval-lethal C. elegans model of spinal muscular atrophy shows mild phenotypes, such as muscle cell and neuronal degeneration, and is therefore useful for testing potential drug treatments.

  • RESOURCE ARTICLE
    CRISPR-Cas9 human gene replacement and phenomic characterization in Caenorhabditis elegans to understand the functional conservation of human genes and decipher variants of uncertain significance
    Troy A. McDiarmid, Vinci Au, Aaron D. Loewen, Joseph Liang, Kota Mizumoto, Donald G. Moerman, Catharine H. Rankin
    Disease Models & Mechanisms 2018 11: dmm036517 doi: 10.1242/dmm.036517 Published 26 November 2018

    Summary: Here, we provide a CRISPR-Cas9 human gene replacement and phenomic characterization strategy to directly replace Caenorhabditis elegans genes with their human orthologs for disease variant modeling and therapeutic screening.

  • RESEARCH ARTICLE
    Modelling brain dopamine-serotonin vesicular transport disease in Caenorhabditis elegans
    Alexander T. Young, Kien N. Ly, Callum Wilson, Klaus Lehnert, Russell G. Snell, Suzanne J. Reid, Jessie C. Jacobsen
    Disease Models & Mechanisms 2018 11: dmm035709 doi: 10.1242/dmm.035709 Published 9 November 2018

    Summary: The first Caenorhabditis elegans model to study brain dopamine-serotonin vesicular transport disease, demonstrating impairment of pharyngeal pumping and grazing phenotypes.

  • RESEARCH ARTICLE
    Genetic and cellular sensitivity of Caenorhabditis elegans to the chemotherapeutic agent cisplatin
    Francisco Javier García-Rodríguez, Carmen Martínez-Fernández, David Brena, Dmytro Kukhtar, Xènia Serrat, Ernest Nadal, Mike Boxem, Sebastian Honnen, Antonio Miranda-Vizuete, Alberto Villanueva, Julián Cerón
    Disease Models & Mechanisms 2018 11: dmm033506 doi: 10.1242/dmm.033506 Published 21 June 2018

    Summary: Caenorhabditis elegans is a valuable model to identify genetic factors influencing the animal response to the widely used chemotherapeutic agent cisplatin.

  • RESEARCH ARTICLE
    Rescue of ATXN3 neuronal toxicity in Caenorhabditis elegans by chemical modification of endoplasmic reticulum stress
    Yasmin Fardghassemi, Arnaud Tauffenberger, Sarah Gosselin, J. Alex Parker
    Disease Models & Mechanisms 2017 10: 1465-1480; doi: 10.1242/dmm.029736

    Summary: We introduce a novel C. elegans model for Machado–Joseph disease for use in preclinical drug discovery and identified guanabenz as a potent neuroprotective molecule.

  • REVIEW
    Caenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseases
    Carmen I. Nussbaum-Krammer, Richard I. Morimoto
    Disease Models & Mechanisms 2014 7: 31-39; doi: 10.1242/dmm.013011

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