supporting biologists inspiring biology

Disease Models & Mechanisms

Brain metastasis

RESEARCH ARTICLE

Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis
Soo-Hyun Kim, Richard P. Redvers, Lap Hing Chi, Xiawei Ling, Andrew J. Lucke, Robert C. Reid, David P. Fairlie, Ana Carolina Baptista Moreno Martin, Robin L. Anderson, Delphine Denoyer, Normand Pouliot

Disease Models & Mechanisms 2018 11: DMM034850 doi: 10.1242/dmm.034850 Published 6 July 2018

Summary: The authors introduce a new syngeneic mouse model of spontaneous breast cancer brain metastasis, demonstrate its phenotypic, functional and transcriptomic relevance to human TNBC brain metastasis, and test novel therapies.