Biomarkers
- Biomarkers for Duchenne muscular dystrophy: myonecrosis, inflammation and oxidative stress
Summary: This Review discusses biomarkers in blood and urine linked to myonecrosis, inflammation and oxidative stress, to enhance development of therapies for DMD, and the challenges to be overcome for clinical translation.
- Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease
Summary: Specific mitochondrial parameters in muscle of a minipig model of Huntington's disease can be used as potential biomarkers of disease progression and suggest that similar pathogenic mechanisms underlie disease progression in TgHD minipigs and HD patients.
- Early and late endothelial response in breast cancer metastasis in mice: simultaneous quantification of endothelial biomarkers using a mass spectrometry-based method
Summary: A microLC/MS-MRM-based approach for simultaneous determination of endothelium-related biomarkers identified glycocalyx disruption, endothelial inflammation and increased endothelial permeability as important events in early pulmonary metastasis in a murine model of breast cancer metastasis.
- Molecular biomarkers of Alzheimer's disease: progress and prospects
Summary: This ‘At a glance’ article summarises the molecular biomarkers of Alzheimer's and related diseases, highlighting the challenges and opportunities for diagnostic and prognostic applications.
- Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease
Summary: Complexin 1 is a prodromal biomarker and risk factor for REM sleep behavior disorder and PARK4-associated Parkinson's disease.
- Longitudinal micro-CT provides biomarkers of lung disease that can be used to assess the effect of therapy in preclinical mouse models, and reveal compensatory changes in lung volume
Summary: Quantifying not only aerated lung volume or lesion volumes but also the total lung volume from micro-CT is essential to document growth as well as potential compensatory mechanisms in the evaluation of mouse models of lung diseases and their therapy.