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Autism

  • REVIEW
    The zebrafish subcortical social brain as a model for studying social behavior disorders
    Yijie Geng, Randall T. Peterson
    Disease Models & Mechanisms 2019 12: dmm039446 doi: 10.1242/dmm.039446 Published 6 August 2019

    Summary: The zebrafish has become an increasingly attractive model for studying social behavior disorders. This Review summarizes relevant methods, established social deficit models, emerging technologies and the anatomical basis of sociality.

  • RESEARCH ARTICLE
    Cacna1c haploinsufficiency leads to pro-social 50-kHz ultrasonic communication deficits in rats
    Theresa M. Kisko, Moria D. Braun, Susanne Michels, Stephanie H. Witt, Marcella Rietschel, Carsten Culmsee, Rainer K. W. Schwarting, Markus Wöhr
    Disease Models & Mechanisms 2018 11: dmm034116 doi: 10.1242/dmm.034116 Published 20 June 2018

    Summary: The present study suggests that Cacna1c plays a prominent role in regulating socio-affective communication in rats with relevance for neuropsychiatric disorders.

  • RESEARCH ARTICLE
    New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes
    Sabiha Abekhoukh, H. Bahar Sahin, Mauro Grossi, Samantha Zongaro, Thomas Maurin, Irene Madrigal, Daniele Kazue-Sugioka, Annick Raas-Rothschild, Mohamed Doulazmi, Pilar Carrera, Andrea Stachon, Steven Scherer, Maria Rita Drula Do Nascimento, Alain Trembleau, Ignacio Arroyo, Peter Szatmari, Isabel M. Smith, Montserrat Milà, Adam C. Smith, Angela Giangrande, Isabelle Caillé, Barbara Bardoni
    Disease Models & Mechanisms 2017 10: 463-474; doi: 10.1242/dmm.025809

    Summary: CYFIP1 and FMRP interact antagonistically during neuromuscular junction growth in the fly and during new neuron differentiation in the olfactory bulb of the adult mouse.

  • RESEARCH ARTICLE
    Hyperactivity and attention deficits in mice with decreased levels of stress-inducible phosphoprotein 1 (STIP1)
    Flavio H. Beraldo, Anu Thomas, Benjamin Kolisnyk, Pedro H. Hirata, Xavier De Jaeger, Amanda C. Martyn, Jue Fan, Daniela F. Goncalves, Matthew F. Cowan, Talal Masood, Vilma R. Martins, Robert Gros, Vania F. Prado, Marco A. M. Prado
    Disease Models & Mechanisms 2015 8: 1457-1466; doi: 10.1242/dmm.022525

    Summary: Here, using a series of behavioral tests including touchscreen tasks we show that decreased levels of stress-inducible phosphoprotein 1 (STIP1) lead to attention deficits and hyperactivity in mice.

  • REVIEW
    Challenges in understanding psychiatric disorders and developing therapeutics: a role for zebrafish
    Jasmine M. McCammon, Hazel Sive
    Disease Models & Mechanisms 2015 8: 647-656; doi: 10.1242/dmm.019620

    Summary: In this review, we discuss strengths and limitations of prevalent laboratory models that are used for understanding psychiatric disorders and developing therapeutics, with emphasis on the zebrafish.

  • RESOURCE ARTICLE
    Introduction of the human AVPR1A gene substantially alters brain receptor expression patterns and enhances aspects of social behavior in transgenic mice
    Rhonda Charles, Takeshi Sakurai, Nagahide Takahashi, Gregory A. Elder, Miguel A. Gama Sosa, Larry J. Young, Joseph D. Buxbaum
    Disease Models & Mechanisms 2014 7: 1013-1022; doi: 10.1242/dmm.017053

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