Animal model
- A novel pancreatic cancer model originated from transformation of acinar cells in adult tree shrew, a primate-like animal
Summary: Our work identified the driver mutations indispensable for PDAC induction from acinar cells in mature adults and established a novel PDAC animal model with increased similarity to human disease.
- An exonic splicing enhancer mutation in DUOX2 causes aberrant alternative splicing and severe congenital hypothyroidism in Bama pigs
Summary: Here, we show that an exonic splicing enhancer variant in DUOX2 (c.1226 A>G) causes aberrant splicing of DUOX2 transcripts, resulting in lower H2O2 production, to cause severe congenital hypothyroidism in Bama pigs.
- Modelling brain dopamine-serotonin vesicular transport disease in Caenorhabditis elegans
Summary: The first Caenorhabditis elegans model to study brain dopamine-serotonin vesicular transport disease, demonstrating impairment of pharyngeal pumping and grazing phenotypes.
- Subchondral drilling for articular cartilage repair: a systematic review of translational research
Summary: Cartilage defects initiate osteoarthritis. This is the first systematic review of translational evidence of cartilage defects in animal models treated by drilling, enhancing translation from basic science to clinical application.
- Inclusion criteria update for the rat intraluminal ischaemic model for preclinical studies
Summary: Laser Doppler monitoring in combination with diffusion-weighted imaging and magnetic resonance angiography represents a reliable inclusion protocol during ischaemic surgery for the analysis of protective drugs in the acute phase of stroke.
- A model of type 2 diabetes in the guinea pig using sequential diet-induced glucose intolerance and streptozotocin treatment
Summary: The guinea pig can act as a tool for investigators interested in the translational manifestations of diabetes using new methods for induction of type 2 diabetes.
- A novel swine model of ricin-induced acute respiratory distress syndrome
Summary: Lung injury induced by intratracheal instillation of ricin to swine exhibits the full set of parameters defining ARDS.
- Standardisation of oxygen exposure in the development of mouse models for bronchopulmonary dysplasia
Summary: A newborn mouse model of bronchopulmonary dysplasia in which oxygen injury is systematically standardised recapitulates the two pathological hallmarks of disease.
- A rat model for hepatitis E virus
Summary: Rat hepatitis E virus strain LA-B350 is used as a model for antiviral studies for hepatitis E virus using a cDNA clone, replicon and in vivo studies.
- Progressive neurologic and somatic disease in a novel mouse model of human mucopolysaccharidosis type IIIC
Summary: A new animal model of the severe neurodegenerative lysosomal disorder mucopolysaccharidosis IIIC recapitulates the human disease, with progressive CNS and somatic lysosomal pathology, and shortened lifespan.