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Animal model

  • RESEARCH ARTICLE
    Differential physiological roles for BIN1 isoforms in skeletal muscle development, function and regeneration
    Ivana Prokic, Belinda S. Cowling, Candice Kutchukian, Christine Kretz, Hichem Tasfaout, Vincent Gache, Josiane Hergueux, Olivia Wendling, Arnaud Ferry, Anne Toussaint, Christos Gavriilidis, Vasugi Nattarayan, Catherine Koch, Jeanne Lainé, Roy Combe, Laurent Tiret, Vincent Jacquemond, Fanny Pilot-Storck, Jocelyn Laporte
    Disease Models & Mechanisms 2020 13: dmm044354 doi: 10.1242/dmm.044354 Published 24 November 2020

    Summary: The BIN1 gene, mutated in centronuclear myopathies, expresses ubiquitous and muscle-specific isoforms. It is shown here that ubiquitous isoforms are necessary for muscle development, whereas muscle-specific isoforms fine-tune muscle regeneration.

  • RESEARCH ARTICLE
    An HIV-Tat inducible mouse model system of childhood HIV-associated nephropathy
    Pingtao Tang, Jharna R. Das, Jinliang Li, Jing Yu, Patricio E. Ray
    Disease Models & Mechanisms 2020 13: dmm045641 doi: 10.1242/dmm.045641 Published 28 October 2020

    Summary: The development of a new inducible mouse model system of childhood HIV-associated nephropathy demonstrated that HIV-Tat plays a critical role in this disease, acting in synergy with other HIV-1 genes and heparin-binding cytokines.

  • REVIEW
    Cellular and animal models for facioscapulohumeral muscular dystrophy
    Alec M. DeSimone, Justin Cohen, Monkol Lek, Angela Lek
    Disease Models & Mechanisms 2020 13: dmm046904 doi: 10.1242/dmm.046904 Published 28 October 2020

    Summary: Owing to its complex etiology and the toxicity of DUX4, modeling facioscapulohumeral muscular dystrophy (FSHD) is uniquely challenging. Here, we review the approaches that overcame these difficulties to develop highly relevant FSHD models.

  • RESEARCH ARTICLE
    Generation and characterization of an Il2rg knockout Syrian hamster model for XSCID and HAdV-C6 infection in immunocompromised patients
    Rong Li, Baoling Ying, Yanan Liu, Jacqueline F. Spencer, Jinxin Miao, Ann E. Tollefson, James D. Brien, Yaohe Wang, William S. M. Wold, Zhongde Wang, Karoly Toth
    Disease Models & Mechanisms 2020 13: dmm044602 doi: 10.1242/dmm.044602 Published 27 August 2020

    Summary: Syrian hamsters are an important rodent species for studying multiple human diseases. We describe the generation and characterization of a hamster strain that is defective in the XCSID-associated IL2RG gene.

  • RESEARCH ARTICLE
    A novel pancreatic cancer model originated from transformation of acinar cells in adult tree shrew, a primate-like animal
    Qiu Tu, Dong Yang, Xianning Zhang, Xintong Jia, Sanqi An, Lanzhen Yan, Hongjuan Dai, Yuhua Ma, Chengwei Tang, Weimin Tong, Zongliu Hou, Longbao Lv, Jing Tan, Xudong Zhao
    Disease Models & Mechanisms 2019 12: dmm038703 doi: 10.1242/dmm.038703 Published 15 April 2019

    Summary: Our work identified the driver mutations indispensable for PDAC induction from acinar cells in mature adults and established a novel PDAC animal model with increased similarity to human disease.

  • RESEARCH ARTICLE
    An exonic splicing enhancer mutation in DUOX2 causes aberrant alternative splicing and severe congenital hypothyroidism in Bama pigs
    Chunwei Cao, Ying Zhang, Qitao Jia, Xiao Wang, Qiantao Zheng, Hongyong Zhang, Ruigao Song, Yongshun Li, Ailing Luo, Qianlong Hong, Guosong Qin, Jing Yao, Nan Zhang, Yanfang Wang, Hongmei Wang, Qi Zhou, Jianguo Zhao
    Disease Models & Mechanisms 2019 12: dmm036616 doi: 10.1242/dmm.036616 Published 15 January 2019

    Summary: Here, we show that an exonic splicing enhancer variant in DUOX2 (c.1226 A>G) causes aberrant splicing of DUOX2 transcripts, resulting in lower H2O2 production, to cause severe congenital hypothyroidism in Bama pigs.

  • RESEARCH ARTICLE
    Modelling brain dopamine-serotonin vesicular transport disease in Caenorhabditis elegans
    Alexander T. Young, Kien N. Ly, Callum Wilson, Klaus Lehnert, Russell G. Snell, Suzanne J. Reid, Jessie C. Jacobsen
    Disease Models & Mechanisms 2018 11: dmm035709 doi: 10.1242/dmm.035709 Published 9 November 2018

    Summary: The first Caenorhabditis elegans model to study brain dopamine-serotonin vesicular transport disease, demonstrating impairment of pharyngeal pumping and grazing phenotypes.

  • RESEARCH ARTICLE
    Subchondral drilling for articular cartilage repair: a systematic review of translational research
    Liang Gao, Lars K. H. Goebel, Patrick Orth, Magali Cucchiarini, Henning Madry
    Disease Models & Mechanisms 2018 11: dmm034280 doi: 10.1242/dmm.034280 Published 19 June 2018

    Summary: Cartilage defects initiate osteoarthritis. This is the first systematic review of translational evidence of cartilage defects in animal models treated by drilling, enhancing translation from basic science to clinical application.

  • RESEARCH ARTICLE
    Inclusion criteria update for the rat intraluminal ischaemic model for preclinical studies
    Héctor Fernández-Susavila, Ramón Iglesias-Rey, Antonio Dopico-López, María Pérez-Mato, Tomás Sobrino, José Castillo, Francisco Campos
    Disease Models & Mechanisms 2017 10: 1433-1438; doi: 10.1242/dmm.029868

    Summary: Laser Doppler monitoring in combination with diffusion-weighted imaging and magnetic resonance angiography represents a reliable inclusion protocol during ischaemic surgery for the analysis of protective drugs in the acute phase of stroke.

  • RESEARCH ARTICLE
    A model of type 2 diabetes in the guinea pig using sequential diet-induced glucose intolerance and streptozotocin treatment
    Brendan K. Podell, David F. Ackart, Michael A. Richardson, James E. DiLisio, Bruce Pulford, Randall J. Basaraba
    Disease Models & Mechanisms 2017 10: 151-162; doi: 10.1242/dmm.025593

    Summary: The guinea pig can act as a tool for investigators interested in the translational manifestations of diabetes using new methods for induction of type 2 diabetes.

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