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Anaemia

  • RESEARCH ARTICLE
    Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency
    Ashlee J. Conway, Fiona C. Brown, Elinor J. Hortle, Gaetan Burgio, Simon J. Foote, Craig J. Morton, Stephen M. Jane, David J. Curtis
    Disease Models & Mechanisms 2018 11: dmm034678 doi: 10.1242/dmm.034678 Published 21 May 2018

    Summary: In a novel ENU mutagenesis mouse model of TPI deficiency, bone marrow transplantation was conducted to demonstrate that haemolytic and red blood cell glycolytic defects can be effectively rescued.

  • RESEARCH ARTICLE
    A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen
    Ashlee J. Conway, Fiona C. Brown, Robert O. Fullinfaw, Benjamin T. Kile, Stephen M. Jane, David J. Curtis
    Disease Models & Mechanisms 2017 10: 1005-1013; doi: 10.1242/dmm.029116

    Summary: A mouse mutagenesis model of hereditary coproporphyria has significant genetic and biochemical parallels to that of the human condition.

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