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AMPK

  • RESEARCH ARTICLE
    Immortalized Parkinson's disease lymphocytes have enhanced mitochondrial respiratory activity
    Sarah J. Annesley, Sui T. Lay, Shawn W. De Piazza, Oana Sanislav, Eleanor Hammersley, Claire Y. Allan, Lisa M. Francione, Minh Q. Bui, Zhi-Ping Chen, Kevin R. W. Ngoei, Flora Tassone, Bruce E. Kemp, Elsdon Storey, Andrew Evans, Danuta Z. Loesch, Paul R. Fisher
    Disease Models & Mechanisms 2016 9: 1295-1305; doi: 10.1242/dmm.025684

    Editors' choice: Cultured Parkinson's disease lymphocytes are metabolically hyperactive, suggesting a new understanding of the underlying cytopathology and biomarkers for this and potentially other neurodegenerative diseases.

  • RESEARCH ARTICLE
    A high-fat jelly diet restores bioenergetic balance and extends lifespan in the presence of motor dysfunction and lumbar spinal cord motor neuron loss in TDP-43A315T mutant C57BL6/J mice
    Karen S. Coughlan, Luise Halang, Ina Woods, Jochen H. M. Prehn
    Disease Models & Mechanisms 2016 9: 1029-1037; doi: 10.1242/dmm.024786

    Summary: A high-fat diet extends lifespan in a TDP-43 mutant mouse model of motor neuron disease and might be a possible treatment strategy for individuals with amyotrophic lateral sclerosis.

  • RESEARCH ARTICLE
    The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia
    Nadia Danilova, Elena Bibikova, Todd M. Covey, David Nathanson, Elizabeth Dimitrova, Yoan Konto, Anne Lindgren, Bertil Glader, Caius G. Radu, Kathleen M. Sakamoto, Shuo Lin
    Disease Models & Mechanisms 2014 7: 895-905; doi: 10.1242/dmm.015495

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